Data from NF1 Inactivation Revs Up Ras in Adult Acute Myelogenous Leukemia

Ebert, Benjamin L.

Data from NF1 Inactivation Revs Up Ras in Adult Acute Myelogenous Leukemia

Posted on 2023-03-31 - 16:25

Abstract

Mutations in the Ras pathway are common in myeloid malignancies. NF1, a tumor suppressor and negative regulator of Ras, is inactivated in a subset of adult acute myelogenous leukemia (AML) cases. Loss of NF1 function sensitizes cells to inhibition of mammalian target of rapamycin (mTOR), a downstream effector of Ras activation, highlighting a potential therapeutic opportunity for some AML patients. Clin Cancer Res; 16(16); 4074–6. ©2010 AACR.

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Mullally, Ann; Ebert, Benjamin L. (2010). Data from NF1 Inactivation Revs Up Ras in Adult Acute Myelogenous Leukemia. American Association for Cancer Research. Collection. https://doi.org/10.1158/1078-0432.c.6519389.v1

https://doi.org/10.1158/1078-0432.c.6519389.v1

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