Novobiocin was orally administered to 2 cases with otitis media owing to staphylococcus, 2 cases with furuncle at the top of nose and at the nape presumably owing to staphylococcus and 14 cases with scarlet fever under simultaneous measurement of it's blood concentration.
The results were as follows:
1) With 4 cases of clear-cut staphylococcus and presumed staphylococcus infection, good effects were obtained with remarkably improved signs and symptoms.
2) A relatively good clinical responsiveness was noted with 14 cases of scarlet fever:
Excellent effect 1 case
Good effect 10 cases
Uncertain effect 3 cases.
3) The serum level of novobiocin was unexpectedly low from an undecided reason, probably from the different method of determination or from the individual difference.