Molecular architecture through self-organization or self-assembly processes of organic compounds has attracted much attention for development of new functional materials. Folic acid forms mesophases in alkaline aqueous solution by tetramedc self-organization through hydrogen bonding. For the development of new supramolecular discotic liquid-crystalline materials, we synthesized folic acid derivatives containing lipophilic long alkyl chains. These compounds exhibited both thermotropic and lyotropic liquid-crystalline phases in wide range of temperatures. Furthermore, complexes of the folic acid derivatives with NaCF_3SO_3 formed thermotropic hexagonal columnar phases, which shows that the self-organized structures were controlled by the addition of alkaline metal salts.