1932

Abstract

This is an evaluative review of the field of prenatal substance exposure, with a focus on neurobiological and behavioral outcomes from infancy to young adulthood. We provide an overall evaluation of the state of the field and comment on current conceptual and methodological issues in need of attention. Although there are many studies of prenatal substance exposure, developmental frameworks that incorporate and reflect the lived experiences of children and families have seldom been employed in this field. In addition, although there are some common effects (e.g., on fetal growth) between major substances, there are also unique effects. Thus, we discuss the role of specific substances but note that polysubstance exposure is common, and models and methods used to date may not be sufficient to advance understanding of coexposure or polyexposure effects. We discuss these conceptual and methodological weaknesses and provide suggestions for future directions.

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2023-12-11
2024-04-28
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Literature Cited

  1. Accornero VH, Anthony JC, Morrow CE, Xue L, Bandstra ES. 2006. Prenatal cocaine exposure: an examination of childhood externalizing and internalizing behavior problems at age 7 years. Epidemol. Psichiatr. Soc. 15:2029
    [Google Scholar]
  2. Ackerman JP, Llorente AM, Black MM, Ackerman CS, Mayes LA, Nair P. 2008. The effect of prenatal drug exposure and caregiving context on children's performance on a task of sustained visual attention. J. Dev. Behav. Pediatr. 29:46774
    [Google Scholar]
  3. Arterberry BJ, Padovano HT, Foster KT, Zucker RA, Hicks BM. 2019. Higher average potency across the United States is associated with progression to first cannabis use disorder symptom. Drug Alcohol Depend. 195:18692
    [Google Scholar]
  4. Baer JS, Sampson PD, Barr HM, Connor PD, Streissguth AP. 2003. A 21-year longitudinal analysis of the effects of prenatal alcohol exposure on young adult drinking. Arch. Gen. Psychiatry 60:37785
    [Google Scholar]
  5. Bandoli G, Coles CD, Kable JA, Wertelecki W, Yevtushok L et al. 2019. Patterns of prenatal alcohol use that predict infant growth and development. Pediatrics 143:e20182399
    [Google Scholar]
  6. Bayrampour H, Zahradnik M, Lisonkova S, Janssen P. 2019. Women's perspectives about cannabis use during pregnancy and the postpartum period: an integrative review. Prev. Med. 119:1723
    [Google Scholar]
  7. Behnke M, Smith VC, Comm. Subst. Abuse 2013. Prenatal substance abuse: short- and long-term effects on the exposed fetus. Pediatrics 131:e100924
    [Google Scholar]
  8. Bennett D, Bendersky M, Lewis M. 2002. Children's intellectual and emotional-behavioral adjustment at 4 years as a function of cocaine exposure, maternal characteristics, and environmental risk. Dev. Psychol. 38:64858
    [Google Scholar]
  9. Black M, Schuler M, Nair P. 1993. Prenatal drug exposure: neurodevelopmental outcome and parenting environment. J. Pediatr. Psychol. 18:60520
    [Google Scholar]
  10. Boggess T, Risher WC. 2022. Clinical and basic research investigations into the long-term effects of prenatal opioid exposure on brain development. J. Neurosci. Res. 100:396409
    [Google Scholar]
  11. Boucher O, Jacobson JL, Burden MJ, Dewailly E, Jacobson SW, Muckle G. 2014. Prenatal tobacco exposure and response inhibition in school-aged children: an event-related potential study. Neurotoxicol. Teratol. 44:8188
    [Google Scholar]
  12. Bridgett DJ, Mayes LC. 2011. Development of inhibitory control among prenatally cocaine exposed and non-cocaine exposed youths from late childhood to early adolescence: the effects of gender and risk and subsequent aggressive behavior. Neurotoxicol. Teratol. 33:4760
    [Google Scholar]
  13. Brocardo PS, Gil-Mohapel J, Wortman R, Noonan A, McGinnis E et al. 2017. The effects of ethanol exposure during distinct periods of brain development on oxidative stress in the adult rat brain. Alcohol Clin. Exp. Res. 41:2637
    [Google Scholar]
  14. Bublitz MH, Stroud LR. 2012. Maternal smoking during pregnancy and offspring brain structure and function: review and agenda for future research. Nicotine Tob. Res. 14:38897
    [Google Scholar]
  15. Buckingham-Howes S, Mazza D, Wang Y, Granger DA, Black MM. 2016. Prenatal drug exposure and adolescent cortisol reactivity: association with behavioral concerns. J. Dev. Behav. Pediatr. 37:56572
    [Google Scholar]
  16. Buss KA, Jaffee S, Wadsworth ME, Kliewer W. 2018. Impact of psychophysiological stress-response systems on psychological development: moving beyond the single biomarker approach. Dev. Psychol. 54:16015
    [Google Scholar]
  17. Cerritelli F, Frasch MG, Antonelli MC, Viglione C, Vecchi S et al. 2021. A review on the vagus nerve and autonomic nervous system during fetal development: searching for critical windows. Front. Neurosci. 15:721605
    [Google Scholar]
  18. Chaplin TM, Visconti KJ, Molfese PJ, Susman EJ, Klein LC et al. 2015. Prenatal cocaine exposure differentially affects stress responses in girls and boys: associations with future substance use. Dev. Psychopathol. 27:16380
    [Google Scholar]
  19. Clark CAC, Espy KA, Wakschlag L. 2016. Developmental pathways from prenatal tobacco and stress exposure to behavioral disinhibition. Neurotoxicol. Teratol. 53:6474
    [Google Scholar]
  20. Coles CD, Kable JA, Lynch ME 2012. Examination of gender differences in effects of tobacco exposure. Gender Differences in Prenatal Substance Exposure M Lewis, L Kestler 99120. Washington, DC: Am. Psychol. Assoc.
    [Google Scholar]
  21. Coles CD, Kalberg W, Kable JA, Tabachnick B, May PA, Chambers CD. 2020. Characterizing alcohol-related neurodevelopmental disorder: prenatal alcohol exposure and the spectrum of outcomes. Alcohol Clin. Exp. Res. 44:124560
    [Google Scholar]
  22. Conradt E, Crowell SE, Lester BM. 2018. Early life stress and environmental influences on the neurodevelopment of children with prenatal opioid exposure. Neurobiol. Stress 9:4854
    [Google Scholar]
  23. Conradt E, Flannery T, Aschner JL, Annett RD, Croen LA et al. 2019. Prenatal opioid exposure: neurodevelopmental consequences and future research priorities. Pediatrics 144:e20190128
    [Google Scholar]
  24. Conradt E, Lagasse LL, Shankaran S, Bada H, Bauer CR et al. 2014. Physiological correlates of neurobehavioral disinhibition that relate to drug use and risky sexual behavior in adolescents with prenatal substance exposure. Dev. Neurosci. 36:30615
    [Google Scholar]
  25. Cornelius MD, De Genna NM, Leech SL, Willford JA, Goldschmidt L, Day NL. 2011. Effects of prenatal cigarette smoke exposure on neurobehavioral outcomes in 10-year-old children of adolescent mothers. Neurotoxicol. Teratol. 33:13744
    [Google Scholar]
  26. Cornelius MD, Goldschmidt L, Day NL. 2012. Prenatal cigarette smoking: long-term effects on young adult behavior problems and smoking behavior. Neurotoxicol. Teratol. 34:55459
    [Google Scholar]
  27. Cornelius MD, Goldschmidt L, DeGenna N, Day NL. 2007. Smoking during teenage pregnancies: effects on behavioral problems in offspring. Nicotine Tob. Res. 9:73950
    [Google Scholar]
  28. Cornelius MD, Leech SL, Goldschmidt L, Day NL. 2000. Prenatal tobacco exposure: Is it a risk factor for early tobacco experimentation?. Nicotine Tob. Res. 2:4552
    [Google Scholar]
  29. Cornelius MD, Leech SL, Goldschmidt L, Day NL. 2005. Is prenatal tobacco exposure a risk factor for early adolescent smoking? A follow-up study. Neurotoxicol. Teratol. 27:66776
    [Google Scholar]
  30. Daigle KM, Heller NA, Sulinski EJ, Shim J, Lindblad W et al. 2020. Maternal responsivity and oxytocin in opioid-dependent mothers. Dev. Psychobiol. 62:2135
    [Google Scholar]
  31. Day NL, Richardson GA, Goldschmidt L, Robles N, Taylor PM et al. 1994. Effect of prenatal marijuana exposure on the cognitive development of offspring at age three. Neurotoxicol. Teratol. 16:16975
    [Google Scholar]
  32. De Genna NM, Goldschmidt L, Cornelius MD. 2015. Maternal patterns of marijuana use and early sexual behavior in offspring of teenage mothers. Matern. Child Health J. 19:62634
    [Google Scholar]
  33. De Genna NM, Goldschmidt L, Day NL, Cornelius MD. 2017. Prenatal tobacco exposure, maternal postnatal nicotine dependence and adolescent risk for nicotine dependence: birth cohort study. Neurotoxicol. Teratol. 61:12832
    [Google Scholar]
  34. De Genna NM, Goldschmidt L, Richardson GA, Cornelius MD, Day NL. 2018. Trajectories of pre- and postnatal co-use of cannabis and tobacco predict co-use and drug use disorders in adult offspring. Neurotoxicol. Teratol. 70:1017
    [Google Scholar]
  35. De Genna NM, Larkby C, Cornelius MD. 2007. Early and adverse experiences with sex and alcohol are associated with adolescent drinking before and during pregnancy. Addict. Behav. 32:2799810
    [Google Scholar]
  36. De Genna NM, Stroud LR, Eiden RD. 2019. Co-use of tobacco and marijuana during pregnancy: impact on nervous system development. Neurotoxicol. Teratol. 74:106807
    [Google Scholar]
  37. Delaney-Black V, Chiodo LM, Hannigan JH, Greenwald MK, Janisse J et al. 2011. Prenatal and postnatal cocaine exposure predict teen cocaine use. Neurotoxicol. Teratol. 33:11019
    [Google Scholar]
  38. Delaney-Black V, Covington C, Nordstrom B, Ager J, Janisse J et al. 2004. Prenatal cocaine: quantity of exposure and gender moderation. J. Dev. Behav. Pediatr. 25:25463
    [Google Scholar]
  39. D'Onofrio BM, Van Hulle CA, Waldman ID, Rodgers JL, Rathouz PJ, Lahey BB. 2007. Causal inferences regarding prenatal alcohol exposure and childhood externalizing problems. Arch. Gen. Psychiatry 64:1296304
    [Google Scholar]
  40. Donald KA, Eastman E, Howells FM, Adnams C, Riley EP et al. 2015. Neuroimaging effects of prenatal alcohol exposure on the developing human brain: a magnetic resonance imaging review. Acta Neuropsychiatr. 27:25169
    [Google Scholar]
  41. Dong C, Chen J, Harrington A, Vinod KY, Hegde ML, Hegde VL. 2019. Cannabinoid exposure during pregnancy and its impact on immune function. Cell Mol. Life Sci. 76:72943
    [Google Scholar]
  42. Doyle LR, Glass L, Wozniak JR, Kable JA, Riley EP et al. 2019. Relation between oppositional/conduct behaviors and executive function among youth with histories of heavy prenatal alcohol exposure. Alcohol Clin. Exp. Res. 43:113544
    [Google Scholar]
  43. Eiden RD. 2018. Etiological processes for substance use disorders beginning in infancy. Alcohol Use Disorders: A Developmental Science Approach to Etiology HE Fitzgerald, LI Puttler 97113. New York: Oxford Univ. Press
    [Google Scholar]
  44. Eiden RD, Ettekal I, Zhao J, Kelm MR, Nickerson AB et al. 2023. Prenatal substance exposure, early-life adversity, and parenting: associations with adolescent stress response. Dev. Psychobiol. 65:e22365
    [Google Scholar]
  45. Eiden RD, Godleski S, Colder CR, Schuetze P. 2014. Prenatal cocaine exposure: the role of cumulative environmental risk and maternal harshness in the development of child internalizing behavior problems in kindergarten. Neurotoxicol. Teratol. 44:110
    [Google Scholar]
  46. Eiden RD, Granger DA, Schuetze P, Vieira Y. 2011a. Child behavior problems among cocaine-exposed toddlers: indirect and interactive effects. Dev. Psychopathol. 23:53950
    [Google Scholar]
  47. Eiden RD, Homish GG, Colder CR, Schuetze P, Gray TR, Huestis MA. 2013. Changes in smoking patterns during pregnancy. Subst. Use Misuse 48:51322
    [Google Scholar]
  48. Eiden RD, Leonard KE, Colder CR, Homish GG, Schuetze P et al. 2011b. Anger, hostility, and aggression as predictors of persistent smoking during pregnancy. J. Stud. Alcohol Drugs 72:92632
    [Google Scholar]
  49. Eiden RD, Lessard J, Colder CR, Livingston J, Casey M, Leonard KE. 2016. Developmental cascade model for adolescent substance use from infancy to late adolescence. Dev. Psychol. 52:161933
    [Google Scholar]
  50. Eiden RD, McAuliffe S, Kachadourian L, Coles CD, Colder CR, Schuetze P. 2009. Effects of prenatal cocaine exposure on infant reactivity and regulation. Neurotoxicol. Teratol. 31:6068
    [Google Scholar]
  51. Eiden RD, Molnar DS, Granger DA, Colder CR, Schuetze P, Huestis MA. 2015. Prenatal tobacco exposure and infant stress reactivity: role of child sex and maternal behavior. Dev. Psychobiol. 57:21225
    [Google Scholar]
  52. Eiden RD, Molnar DS, Leonard KE, Colder CR, Homish GG et al. 2011c. Sources and frequency of secondhand smoke exposure during pregnancy. Nicotine Tob. Res. 13:65360
    [Google Scholar]
  53. Eiden RD, Schuetze P, Colder CR, Veira Y. 2011d. Maternal cocaine use and mother–toddler aggression. Neurotoxicol. Teratol. 33:36069
    [Google Scholar]
  54. Eiden RD, Schuetze P, Coles CD. 2011e. Maternal cocaine use and mother–infant interactions: direct and moderated associations. Neurotoxicol. Teratol. 33:12028
    [Google Scholar]
  55. Eiden RD, Schuetze P, Shisler S, Huestis MA. 2018a. Prenatal exposure to tobacco and cannabis: effects on autonomic and emotion regulation. Neurotoxicol. Teratol. 68:4756
    [Google Scholar]
  56. Eiden RD, Shisler S, Granger DA, Schuetze P, Colangelo J, Huestis MA. 2020. Prenatal tobacco and cannabis exposure: associations with cortisol reactivity in early school age children. Int. J. Behav. Med. 27:34356
    [Google Scholar]
  57. Eiden RD, Zhao J, Casey M, Shisler S, Schuetze P, Colder CR. 2018b. Pre- and postnatal tobacco and cannabis exposure and child behavior problems: bidirectional associations, joint effects, and sex differences. Drug Alcohol Depend. 185:8292
    [Google Scholar]
  58. El Marroun H, Bolhuis K, Franken IH, Jaddoe VW, Hillegers MH et al. 2019. Preconception and prenatal cannabis use and the risk of behavioural and emotional problems in the offspring; a multi-informant prospective longitudinal study. Int. J. Epidemiol. 48:28796
    [Google Scholar]
  59. El Marroun H, Hudziak JJ, Tiemeier H, Creemers H, Steegers EA et al. 2011. Intrauterine cannabis exposure leads to more aggressive behavior and attention problems in 18-month-old girls. Drug Alcohol Depend. 118:47074
    [Google Scholar]
  60. El Marroun H, Schmidt MN, Franken IH, Jaddoe VW, Hofman A et al. 2014. Prenatal tobacco exposure and brain morphology: a prospective study in young children. Neuropsychopharmacology 39:792800
    [Google Scholar]
  61. Estabrook R, Massey SH, Clark CAC, Burns JL, Mustanski BS et al. 2016. Separating family-level and direct exposure effects of smoking during pregnancy on offspring externalizing symptoms: bridging the behavior genetic and behavior teratologic divide. Behavior Genet. 46:389402
    [Google Scholar]
  62. Ettekal I, Eiden RD, Nickerson AB, Molnar DS, Schuetze P. 2020. Developmental cascades to children's conduct problems: the role of prenatal substance use, socioeconomic adversity, maternal depression and sensitivity, and children's conscience. Dev. Psychopathol. 32:85103
    [Google Scholar]
  63. Evans GW, Li D, Whipple SS. 2013. Cumulative risk and child development. Psychol. Bull. 139:134296
    [Google Scholar]
  64. Froggatt S, Covey J, Reissland N. 2020. Infant neurobehavioural consequences of prenatal cigarette exposure: a systematic review and meta-analysis. Acta Paediatr. 109:111224
    [Google Scholar]
  65. Gartstein MA, Skinner MK. 2018. Prenatal influences on temperament development: the role of environmental epigenetics. Dev. Psychopathol. 30:1269303
    [Google Scholar]
  66. Godleski SA, Eiden RD, Schuetze P, Colder CR, Huestis MA. 2016. Tobacco exposure and maternal psychopathology: Impact on toddler problem behavior. Neurotoxicol. Teratol. 57:8794
    [Google Scholar]
  67. Godleski SA, Shisler S, Eiden RD, Huestis MA. 2018. Co-use of tobacco and marijuana during pregnancy: pathways to externalizing behavior problems in early childhood. Neurotoxicol. Teratol. 69:3948
    [Google Scholar]
  68. Gosdin LK, Deputy NP, Kim SY, Dang EP, Denny CH. 2022. Alcohol consumption and binge drinking during pregnancy among adults aged 18–49 years—United States, 2018–2020. Morb. Mortal. Wkly. Rep. 71:1013. Erratum 2022. Morb. Mortal. Wkly. Rep. 71:156
    [Google Scholar]
  69. Graeve R, Balalian AA, Richter M, Kielstein H, Fink A et al. 2022. Infants’ prenatal exposure to opioids and the association with birth outcomes: a systematic review and meta-analysis. Paediatr. Perinat. Epidemiol. 36:12543
    [Google Scholar]
  70. Grewen K, Salzwedel AP, Gao W. 2015. Functional connectivity disruption in neonates with prenatal marijuana exposure. Front. Hum. Neurosci. 9:601
    [Google Scholar]
  71. Haight SC, King BA, Bombard JM, Coy KC, Ferré CD et al. 2021. Frequency of cannabis use during pregnancy and adverse infant outcomes, by cigarette smoking status – 8 PRAMS states, 2017. Drug Alcohol Depend. 220:108507
    [Google Scholar]
  72. Hanlon-Dearman AC, Narvey S. 2022. Approach to managing behavior in FASD. Fetal Alcohol Spectrum Disorder: Advances in Research and Practice AE Chudley, GG Hicks 14366. New York: Humana Press
    [Google Scholar]
  73. Hellemans KG, Sliwowska JH, Verma P, Weinberg J. 2010. Prenatal alcohol exposure: fetal programming and later life vulnerability to stress, depression and anxiety disorders. Neurosci. Biobehav. Rev. 34:791807
    [Google Scholar]
  74. Henderson J, Gray R, Brocklehurst P. 2007. Systematic review of effects of low-moderate prenatal alcohol exposure on pregnancy outcome. BJOG 114:24352. Corrigendum BJOG 114:91415
    [Google Scholar]
  75. Hepper PG, Dornan JC, Lynch C. 2012. Fetal brain function in response to maternal alcohol consumption: early evidence of damage. Alcohol Clin. Exp. Res. 36:216875
    [Google Scholar]
  76. Hirai AH, Ko JY, Owens PL, Stocks C, Patrick SW. 2021. Neonatal abstinence syndrome and maternal opioid-related diagnoses in the US, 2010–2017. JAMA 325:14655
    [Google Scholar]
  77. Horn SR, Roos LE, Berkman ET, Fisher PA. 2018. Neuroendocrine and immune pathways from pre- and perinatal stress to substance abuse. Neurobiol. Stress 9:14050
    [Google Scholar]
  78. Huizink AC. 2014. Prenatal cannabis exposure and infant outcomes: overview of studies. Prog. Neuropsychopharmacol. Biol. Psychiatry 52:4552
    [Google Scholar]
  79. Huizink AC, de Rooij SR. 2018. Prenatal stress and models explaining risk for psychopathology revisited: generic vulnerability and divergent pathways. Dev. Psychopathol. 30:104162
    [Google Scholar]
  80. Jacobson JL, Akkaya-Hocagil T, Ryan LM, Dodge NC, Richardson GA et al. 2021. Effects of prenatal alcohol exposure on cognitive and behavioral development: findings from a hierarchical meta-analysis of data from six prospective longitudinal US cohorts. Alcohol Clin. Exp. Res. 45:204058
    [Google Scholar]
  81. Jaddoe VWV, van Duijn CM, Franco OH, van der Heijden AJ, van IIzendoorn MH et al. 2012. The Generation R Study: design and cohort update 2012. Eur. J. Epidemiol. 27:73956
    [Google Scholar]
  82. Jones HE, Finnegan LP, Kaltenbach K. 2012. Methadone and buprenorphine for the management of opioid dependence in pregnancy. Drugs 72:74757
    [Google Scholar]
  83. Jones K, Smith D. 1973. Recognition of the fetal alcohol syndrome in early infancy. Lancet 302:9991001
    [Google Scholar]
  84. Jordan CJ, Weiss SRB, Howlett KD, Freund MP. 2020. Introduction to the special issue on “informing longitudinal studies on the effects of maternal stress and substance use on child development: planning for the HEALthy Brain and Child Development (HBCD) Study. .” Advers. Resil. Sci. 1:21721
    [Google Scholar]
  85. Karmel BZ, Gardner JM. 1996. Prenatal cocaine exposure effects on arousal-modulated attention during the neonatal period. Dev. Psychobiol. 29:46380
    [Google Scholar]
  86. Kim S, Selya A, Wakschlag LS, Dierker L, Rose JS et al. 2021. Estimating causal and time-varying effects of maternal smoking on youth smoking. Addict. Behav. 120:106982
    [Google Scholar]
  87. Knopik VS, Heath AC, Bucholz KK, Madden PA, Waldron M. 2009. Genetic and environmental influences on externalizing behavior and alcohol problems in adolescence: a female twin study. Pharmacol. Biochem. Behav. 93:31321
    [Google Scholar]
  88. Ko JY, Coy KC, Haight SC, Haegerich TM, Williams L et al. 2020a. Characteristics of marijuana use during pregnancy—eight states, pregnancy risk assessment monitoring system; 2017. Morbid. Mortal. Wkly. Rep. 69:105863
    [Google Scholar]
  89. Ko JY, D'Angelo DV, Haight SC, Morrow B, Cox S et al. 2020b. Vital signs: prescription opioid pain reliever use during pregnancy—34 US jurisdictions; 2019. Morbid. Mortal. Wkly. Rep. 69:897903
    [Google Scholar]
  90. Kunkler C, Lewis AJ, Almeida R. 2022. Methamphetamine exposure during pregnancy: a meta-analysis of child developmental outcomes. Neurosci. Biobehav. Rev. 138:104714
    [Google Scholar]
  91. Labella MH, Eiden RD, Tabachnick AR, Sellers T, Dozier M. 2021. Infant neurodevelopmental outcomes of prenatal opioid exposure and polysubstance use. Neurotoxicol. Teratol. 86:107000
    [Google Scholar]
  92. Lan N, Chiu MP, Ellis L, Weinberg J. 2017. Prenatal alcohol exposure and prenatal stress differentially alter glucocorticoid signaling in the placenta and fetal brain. Neuroscience 342:16779
    [Google Scholar]
  93. Lebel C, Roussotte F, Sowell ER. 2011. Imaging the impact of prenatal alcohol exposure on the structure of the developing human brain. Neuropsychol. Rev. 21:10218
    [Google Scholar]
  94. Lee SJ, Bora S, Austin NC, Westerman A, Henderson JMT. 2020. Neurodevelopmental outcomes of children born to opioid-dependent mothers: a systematic review and meta-analysis. Acad. Pediatr. 20:30818
    [Google Scholar]
  95. Lester B, Bada H, Bauer C, Shankaran S, Whitaker T et al. 2016. Maternal lifestyle study in four sites in the United States, 1993–2011 Rep. Natl. Addict. HIV Data Arch. Program, Inter-Univ. Consort. Political Soc. Res. Ann Arbor, MI:
  96. Lester BM, LaGasse LL, Shankaran S, Bada HS, Bauer CR et al. 2010. Prenatal cocaine exposure related to cortisol stress reactivity in 11-year-old children. J. Pediatr. 157:28895
    [Google Scholar]
  97. Lester BM, Padbury JF. 2009. Third pathophysiology of prenatal cocaine exposure. Dev. Neurosci. 31:2335
    [Google Scholar]
  98. Li Z, Santhanam P, Coles CD, Lynch ME, Hamann S et al. 2011. Increased ‘default mode’ activity in adolescents prenatally exposed to cocaine. Hum. Brain Mapp. 32:75970
    [Google Scholar]
  99. Li Z, Santhanam P, Coles CD, Lynch ME, Hamann S et al. 2013. Prenatal cocaine exposure alters functional activation in the ventral prefrontal cortex and its structural connectivity with the amygdala. Psychiatry Res. Neuroimaging 213:4755
    [Google Scholar]
  100. Light KC, Grewen KM, Amico JA, Boccia M, Brownley KA, Johns JM. 2004. Deficits in plasma oxytocin responses and increased negative affect, stress, and blood pressure in mothers with cocaine exposure during pregnancy. Addict. Behav. 29:154164
    [Google Scholar]
  101. Long X, Lebel C. 2022. Evaluation of brain alterations and behavior in children with low levels of prenatal alcohol exposure. JAMA Netw. Open. 5:e225972
    [Google Scholar]
  102. Longo CA, Fried PA, Cameron I, Smith AM 2013. The long-term effects of prenatal nicotine exposure on response inhibition: an fMRI study of young adults. Neurotoxicol. Teratol. 39:918
    [Google Scholar]
  103. Lowell AF, Morie K, Potenza MN, Crowley MJ, Mayes LC. 2022. An intergenerational lifespan perspective on the neuroscience of prenatal substance exposure. Pharmacol. Biochem. Behav. 219:173445
    [Google Scholar]
  104. Marceau K, Horvath G, Loviska AM, Knopik VS. 2021. Developmental cascades from polygenic and prenatal substance use to adolescent substance use: leveraging severity and directionality of externalizing and internalizing problems to understand pubertal and harsh discipline-related risk. Behav. Genet. 51:55979
    [Google Scholar]
  105. Marchand G, Masoud AT, Govindan M, Ware K, King A et al. 2022. Birth outcomes of neonates exposed to marijuana in utero. JAMA Netw. Open 5:e2145653
    [Google Scholar]
  106. Mattson SN, Bernes GA, Doyle LR. 2019. Fetal alcohol spectrum disorders: a review of the neurobehavioral deficits associated with prenatal alcohol exposure. Alcohol Clin. Exp. Res. 43:104662
    [Google Scholar]
  107. Mattson SN, Riley EP. 2000. Parent ratings of behavior in children with heavy prenatal alcohol exposure and IQ-matched controls. Alcohol Clin. Exp. Res. 24:22631
    [Google Scholar]
  108. Mayes LC, Granger RH, Bornstein MH, Zuckerman B. 1992. The problem of prenatal cocaine exposure: a rush to judgment. JAMA 267:4068
    [Google Scholar]
  109. McGue M, Bouchard TJ Jr. 1998. Genetic and environmental influences on human behavioral differences. Annu. Rev. Neurosci. 21:124
    [Google Scholar]
  110. McMurray MS, Joyner PW, Middleton CW, Jarrett TM, Elliott DL et al. 2008. Intergenerational effects of cocaine on maternal aggressive behavior and brain oxytocin in rat dams. Stress 11:398410
    [Google Scholar]
  111. Min MO, Minnes S, Kim S-K, Kim J-Y, Singer LT. 2023. Prenatal cocaine exposure and substance use disorder in emerging adulthood at age 21. Drug Alcohol Depend. 242:109736
    [Google Scholar]
  112. Min MO, Minnes S, Lang A, Weishampel P, Short EJ et al. 2014. Externalizing behavior and substance use related problems at 15 years in prenatally cocaine exposed adolescents. J. Adolesc. 37:26979
    [Google Scholar]
  113. Minnes S, Singer LT, Min MO, Lang AM, Ben-Harush A et al. 2014. Comparison of 12-year-old children with prenatal exposure to cocaine and non-exposed controls on caregiver ratings of executive function. J. Youth Adolesc. 43:5369
    [Google Scholar]
  114. Molnar DS, Levitt A, Eiden RD, Schuetze P. 2014. Prenatal cocaine exposure and trajectories of externalizing behavior problems in early childhood: examining the role of maternal negative affect. Dev. Psychopathol. 26:51528
    [Google Scholar]
  115. Morie KP, Crowley MJ, Mayes LC, Potenza MN. 2019. Prenatal drug exposure from infancy through emerging adulthood: results from neuroimaging. Drug Alcohol Depend. 198:3953
    [Google Scholar]
  116. Murnan AW, Keim SA, Yeates KO, Boone KM, Sheppard KW, Klebanoff MA. 2021. Behavioral and cognitive differences in early childhood related to prenatal marijuana exposure. J. Appl. Dev. Psychol. 77:101348
    [Google Scholar]
  117. Newman AI, Mauer-Vakil D, Coo H, Newton L, Wilkerson E et al. 2022. Rooming-in for infants at risk for neonatal abstinence syndrome: outcomes 5 years following its introduction as the standard of care at one hospital. Am. J. Perinatol. 39:897903
    [Google Scholar]
  118. NIDA (Natl. Inst. Drug Abuse) 2020. Substance use while pregnant and breastfeeding Rep. Natl. Inst. Drug Abuse Gaithersburg, MD: https://nida.nih.gov/publications/research-reports/substance-use-in-women/substance-use-while-pregnant-breastfeeding
  119. Oberlander TF, Jacobson SW, Weinberg J, Grunau RE, Molteno CD, Jacobson JL. 2010. Prenatal alcohol exposure alters biobehavioral reactivity to pain in newborns. Alcohol Clin. Exp. Res. 34:68192
    [Google Scholar]
  120. Oei JL. 2020. Alcohol use in pregnancy and its impact on the mother and child. Addiction 115:214863
    [Google Scholar]
  121. Oh K, Xu Y, Terrizzi BF, Lanphear B, Chen A et al. 2020. Associations between early low-level tobacco smoke exposure and executive function at age 8 years. J. Pediatr. 221:17480.e1
    [Google Scholar]
  122. Oh S, Gonzalez JMR, Salas-Wright CP, Vaughn MG, DiNitto DM. 2017. Prevalence and correlates of alcohol and tobacco use among pregnant women in the United States: evidence from the NSDUH 2005–2014. Prev. Med. 97:9399
    [Google Scholar]
  123. Ostlund BD, Pérez-Edgar KE, Shisler S, Terrell S, Godleski S et al. 2021. Prenatal substance exposure and maternal hostility from pregnancy to toddlerhood: associations with temperament profiles at 16 months of age. Dev. Psychopathol. 33:156683
    [Google Scholar]
  124. Ostrov JM, Perry KJ, Eiden RD, Nickerson AB, Schuetze P et al. 2022. Development of bullying and victimization: an examination of risk and protective factors in a high-risk sample. J. Interpers. Violence 37:595884
    [Google Scholar]
  125. Patrick SW, Barfield WD, Poindexter BB, Comm. Fetus Newborn, Comm. Subst. Use Prev 2020. Neonatal opioid withdrawal syndrome. Pediatrics 146:e2020029074
    [Google Scholar]
  126. Petimar J, Rifas-Shiman SL, Hivert MF, Fleisch AF, Tiemeier H, Oken E. 2020. Prenatal and childhood predictors of hair cortisol concentration in mid-childhood and early adolescence. PLOS ONE 15:e0228769
    [Google Scholar]
  127. Porath AJ, Fried PA. 2005. Effects of prenatal cigarette and marijuana exposure on drug use among offspring. Neurotoxicol. Teratol. 27:26777
    [Google Scholar]
  128. Propper CB, Holochwost SJ. 2013. The influence of proximal risk on the early development of the autonomic nervous system. Dev. Rev. 33:15167
    [Google Scholar]
  129. Reid N, Petrenko CLM. 2018. Applying a developmental framework to the self-regulatory difficulties of young children with prenatal alcohol exposure: a review. Alcohol Clin. Exp. Res. 42:9871005
    [Google Scholar]
  130. Richardson GA, De Genna NM, Goldschmidt L, Larkby C, Donovan JE. 2019. Prenatal cocaine exposure: direct and indirect associations with 21-year-old offspring substance use and behavior problems. Drug Alcohol Depend. 195:12131
    [Google Scholar]
  131. Robinson SM, Sobell LC, Sobell MB, Leo GI. 2014. Reliability of the Timeline Followback for cocaine, cannabis, and cigarette use. Psychol. Addict. Behav. 28:15462
    [Google Scholar]
  132. Rückinger S, Rzehak P, Chen C-M, Sausenthaler S, Koletzko S et al. 2010. Prenatal and postnatal tobacco exposure and behavioral problems in 10-year-old children: results from the GINI-plus prospective birth cohort study. Environ. Health Perspect. 118:15054
    [Google Scholar]
  133. Rutherford HJV, Potenza MN, Mayes LC 2013. The neurobiology of addiction and attachment. Parenting and Substance Abuse: Developmental Approaches to Intervention NE Suchman, M Pajulo, LC Mayes 323. New York: Oxford Univ. Press
    [Google Scholar]
  134. Salisbury AL, Ponder KL, Padbury JF, Lester BM. 2009. Fetal effects of psychoactive drugs. Clin. Perinatol. 36:595619
    [Google Scholar]
  135. Sanders JL. 2009. Were our forebears aware of prenatal alcohol exposure and its effects? A review of the history of fetal alcohol spectrum disorder. Can. J. Clin. Pharmacol. 16:e28895
    [Google Scholar]
  136. Scheyer AF, Melis M, Trezza V, Manzoni OJJ. 2019. Consequences of perinatal cannabis exposure. Trends Neurosci. 42:87184
    [Google Scholar]
  137. Schlatterer SD, du Plessis AJ. 2021. Exposures influencing the developing central autonomic nervous system. Birth Defects Res. 113:84563
    [Google Scholar]
  138. Schuetze P, Eiden RD. 2006. The association between maternal smoking and secondhand exposure and autonomic functioning at 2–4 weeks of age. Infant Behav. Dev. 29:3243
    [Google Scholar]
  139. Schuetze P, Eiden RD, Colder CR, Gray TR, Huestis MA. 2011. Physiological regulation in cigarette exposed infants: an examination of potential moderators. Neurotoxicol. Teratol. 33:56774
    [Google Scholar]
  140. Schuetze P, Eiden RD, Colder CR, Gray TR, Huestis MA. 2013. Physiological regulation at 9 months of age in infants prenatally exposed to cigarettes. Infancy 18:23355
    [Google Scholar]
  141. Schuetze P, Eiden RD, Colder CR, Huestis MA, Leonard KE. 2018. Prenatal risk and infant regulation: indirect pathways via fetal growth and maternal prenatal stress and anger. Child Dev. 89:e12337
    [Google Scholar]
  142. Schuetze P, Eiden RD, Coles CD. 2007. Prenatal cocaine and other substance exposure: effects on infant autonomic regulation at 7 months of age. Dev. Psychobiol. 49:27689
    [Google Scholar]
  143. Schuetze P, Eiden RD, Danielewicz S. 2009. The association between prenatal cocaine exposure and physiological regulation at 13 months of age. J. Child. Psychol. Psychiatry 50:14019
    [Google Scholar]
  144. Schuetze P, Eiden RD, Shisler S. 2020a. Autonomic functioning among cocaine-exposed kindergarten-aged children: examination of child sex and caregiving environmental risk as potential moderators. Neurotoxicol. Teratol. 80:106889
    [Google Scholar]
  145. Schuetze P, Godleski S, Sassaman J. 2021. Prenatal exposure to opioids: associations between the caregiving environment and externalizing behaviors. Neurotoxicol. Teratol. 87:107019
    [Google Scholar]
  146. Schuetze P, Molnar D, Eiden RD, Shisler S, Zhao J et al. 2020b. The effect of prenatal adversity on externalizing behaviors at 24 months of age in a high-risk sample: maternal sensitivity as a moderator. Infant. Ment. Health J. 41:53042
    [Google Scholar]
  147. Schuetze P, Zhao J, Eiden RD, Shisler S, Huestis MA. 2019. Prenatal exposure to tobacco and marijuana and child autonomic regulation and reactivity: an analysis of indirect pathways via maternal psychopathology and parenting. Dev. Psychobiol. 61:102234
    [Google Scholar]
  148. Seay DM, Ivanova MY, Nickerson AB, Godleski S, Schuetze P, Eiden RD. 2023. Family risk exposure profiles during early childhood: Developmental processes and adolescent well-being. Advers. Resil. Sci. 4:15170
    [Google Scholar]
  149. Shisler S, Eiden RD, Molnar DS, Schuetze P, Huestis M, Homish G. 2017. Smoking in pregnancy and fetal growth: the case for more intensive assessment. Nicotine Tob. Res. 19:52531
    [Google Scholar]
  150. Shisler S, Homish GG, Molnar DS, Schuetze P, Colder CR, Eiden RD. 2015. Predictors of changes in smoking from third trimester to 9 months postpartum. Nicotine Tob. Res. 18:8487
    [Google Scholar]
  151. Singer LT, Eisengart LJ, Minnes S, Noland J, Jey A et al. 2005. Prenatal cocaine exposure and infant cognition. Infant Behav. Dev. 28:43144
    [Google Scholar]
  152. Smith BL. 2021. Improving translational relevance: the need for combined exposure models for studying prenatal adversity. Brain Behav. Immun. 16:100294
    [Google Scholar]
  153. Smith LM, Diaz S, LaGasse LL, Wouldes T, Derauf C et al. 2015. Developmental and behavioral consequences of prenatal methamphetamine exposure: a review of the Infant Development, Environment, and Lifestyle (IDEAL) study. Neurotoxicol. Teratol. 51:3544
    [Google Scholar]
  154. Stroud LR, Papandonatos GD, Jao NC, Vergara-Lopez C, Huestis MA, Salisbury AL. 2020. Prenatal tobacco and marijuana co-use: sex-specific influences on infant cortisol stress response. Neurotoxicol. Teratol. 79:106882
    [Google Scholar]
  155. Stroud LR, Papandonatos GD, McCallum M, Kehoe T, Salisbury AL, Huestis MA. 2018. Prenatal tobacco and marijuana co-use: impact on newborn neurobehavior. Neurotoxicol. Teratol. 70:2839
    [Google Scholar]
  156. Tabachnick AR, Eiden RD, Labella MH, Dozier M. 2022. Effects of an attachment-based intervention on autonomic regulation among opioid-exposed infants. Dev. Psychobiol. 64:e22286
    [Google Scholar]
  157. Thompson BL, Levitt P, Stanwood GD. 2009. Prenatal exposure to drugs: effects on brain development and implications for policy and education. Nat. Rev. Neurosci. 10:30312
    [Google Scholar]
  158. Tran EL, England LJ, Park Y, Denny CH, Kim SY. 2023. Systematic review: polysubstance prevalence estimates reported during pregnancy, US, 2009–2020. Matern. Child Health J. 27:42658
    [Google Scholar]
  159. Volkow ND, Han B, Compton WM, McCance-Katz EF. 2019. Self-reported medical and nonmedical cannabis use among pregnant women in the United States. JAMA 322:16769
    [Google Scholar]
  160. Wakschlag LS, Leventhal BL, Pine DS, Pickett KE, Carter AS. 2006a. Elucidating early mechanisms of developmental psychopathology: the case of prenatal smoking and disruptive behavior. Child Dev. 77:893906
    [Google Scholar]
  161. Wakschlag LS, Pickett KE, Kasza KE, Loeber R. 2006b. Is prenatal smoking associated with a developmental pattern of conduct problems in young boys?. J. Am. Acad. Child Adolesc. Psychiatry 45:46167
    [Google Scholar]
  162. Wiebe SA, Clark CAC, De Jong DM, Chevalier N, Espy KA, Wakschlag L 2015. Prenatal tobacco exposure and self-regulation in early childhood: implications for developmental psychopathology. Dev. Psychopathol. 27:397409
    [Google Scholar]
  163. Willford JA, Herat A, Richardson GA. 2018. An examination of the association between prenatal cocaine exposure and brain activation measures of arousal and attention in young adults: an fMRI study using the Attention Network Task. Neurotoxicol. Teratol. 69:110
    [Google Scholar]
  164. Witherspoon DP, Stein GL 2023. Developmental science in the twenty-first century: moving forward to integrate cultural and racial processes into research. Diversity and Developmental Science: Bridging the Gaps Between Research, Practice, and Policy DP Witherspoon, GL Stein 33542. Cham, Switz.: Springer
    [Google Scholar]
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