Chronic lymphocytic leukemia (CLL) has been known to have a higher incidence of cancer than other types of leukemia and relationship between CLL and cancer has been emphasized. In Japan, however, reports of such cases are few.
We have recently encountered two cases of CLL associated with cancer.
The first case, 60-year-old woman, has developed to cancer of the pancreas after 12 years course of CLL.
The second case, 76 year-old-woman, has been discovered CLL and cancer of the left breast simulataneously.
Case reports of CLL associated with cancer from the literature were reviewed and discussed.