Nanohybridization of various biomolecules with layered double hydroxides and hydroxy double salts has been explored for the advanced applications, especially, safe and controlled delivery of pharmaceutical, cosmetic, and agrochemical ingredients. This review deals with LDH and HDS nanohybrids for cosmetic applications along with a brief introduction of their pharmaceutical applications. LDH and HDS nanohybrids have been synthesized by coprecipitation and ion exchange routes those which lead to stabilization of the biomolecules within the interlayer space of those lamellar materials. The intercalated biomolecules are released mainly by ion-exchange and difffusion-facilitated processes. Bioactivities of the nanohybrids are remarkably improved compared to those of the free biomolecules. This review strongly supports that nanohybridization of biomolecules with layered metal hydroxides leads to the enhanced efficiency as well as the protected and release-controlled delivery of various biomolecules, especially unstable ones.