You are here

Article Text

Article menu

Download PDFPDF

E-Posters
E-Poster Viewing
EPV058/#315 Association of hla-g polymorphisms with high-risk HPV+ cervical pathologies susceptibility
Free
  1. I Zidi1,
  2. I Zemni1,2,
  3. K Tizaoui1,
  4. HI Ouzari1 and
  5. N Boujelbene1,3
  1. 1Sciences Faculty of Tunis, University of Tunis El Manar, Laboratory of Microorganismes and Active Biomolecules, Tunis, Tunisia
  2. 2Salah Azaiez Institute of Cancerology, University of Tunis El Manar, Department of Surgical Oncology, Tunis, Tunisia
  3. 3Salah Azaiez Institute of Cancerology, University of Tunis El Manar, Department of Pathology, Tunis, Tunisia

Abstract

Objectives HLA-G gene polymorphisms have been linked to many cancers particularly to cervical squamous cell carcinoma (CSCC). In this meta-analysis, we studied the association of HLA-G +3142 C/G and 14bp Insertion/deletion (Ins/Del) polymorphisms with cervical pathologies susceptibility.

Methods A comprehensive systematic literature search in Medline, Pubmed, Cochrane, Embase, and Web of Science databases was performed to look up relevant studies. We identified four studies for HLA-G +3142 C/G (299 patients with HPV+ high-risk cervical pathologies and 870 healthy controls (HC)); and six studies for HLA-G14bp Ins/Del (693 patients with HPV+ high-risk cervical pathologies and 2536 HC). The association was studied through the calculation of the odds ratio (OR) and the corresponding 95% confidence interval (CI).

Results HLA-G +3142 C/G polymorphism and HLA-G 14 bp Ins/Del significantly enhanced the risk for HPV+ cervical pathologies only in Asians conversely to overall population and Caucasians. HLA-G +3142 C/G enhanced the HPV+ high-risk cervical pathologies risk under allelic C vs. G model (OR=1.321, 95CI%=1.035–1.686, p=0.025) and under the genotypic model CC vs. GG+GC (OR=2.028, 95CI%=1.337–3.075, p=0.001). HLA-G 14bp Ins/Del increased also the HPV+ cervical pathologies risk only under the genetic model (InsIns vs. DelDel+InsDel) (OR=1.910, 95%CI=1.151–3.171, p=0.012) in Asians.

Conclusions Our preliminary meta-analysis showed a significant association of HLA-G +3142 C/G polymorphism and HLA-G 14bp Ins/Del with HPV+ high-risk cervical pathologies susceptibility in Asians. Further studies still needed in other ethnicities to clearly establish our findings.

https://doi.org/10.1136/ijgc-2021-IGCS.126

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.