Article Text

Download PDFPDF
Is there any relationship between IEL and lymphoid follicles in the gastric mucosa?
  1. G CAMMAROTA,
  2. G GASBARRINI
  1. Catholic University of Rome, Italy
  1. Dr G Cammarota, Policlinico “A Gemelli”, Università Cattolica del Sacro Cuore, Istituto di Medicina Interna e Geriatria, Largo A.Gemelli, 8–00168, Roma, Italy. Email: gcammarota{at}libero.it

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Editor,—The article by Hayatet al (OpenUrlPubMed) reporting the decrease in intraepithelial lymphocytes (IEL) in the gastric mucosa afterHelicobacter pylori eradication is interesting and confirms the suggestion that lymphocytic gastritis could be a manifestation of an atypical host immune response toH pylori. But we would like to ask Dr Hayat and colleagues whether they also investigated the presence of lymphoid follicles in the lamina propria of gastric mucosa of their patients. In fact, mucosa associated lymphoid tissue (MALT), organised in follicles with a germinative centre and B cell reactivity, which structurally resemble Peyer's patches, can develop in the lamina propria afterH pylori infection.1 ,2 Also, the development of these reactive lymphoid follicles may depend on the characteristics of the host and stimuli other thanH pylori. We found lymphoid follicles in the gastric mucosa of 30% of our coeliac patients, of whom only 38% were …

View Full Text