Article Text

Download PDFPDF
Naltrexone for 3 or 12 months did not reduce drinking in alcohol dependence

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


 
 QUESTION: In patients with alcohol dependence and a recent history of drinking to intoxication, is treatment with naltrexone for 3 or 12 months in addition to standardised psychosocial treatment more effective than placebo for reducing alcohol consumption?

Design

Randomised {allocation concealed*}, blinded (participants and health care providers),* controlled trial with 52 weeks of follow up.

Setting

15 Veterans Affairs medical centres in the US.

Patients

627 outpatients (mean age 49 y, 98% men) who had a diagnosis of alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders, 4th ed, criteria; who had not drunk for ≥ 5 days; and who had a recent history of drinking to intoxication (≥ 6 drinks for men and ≥ 4 drinks for women at least twice during a 1 wk period in the 30 d before screening). Exclusion criteria included previous …

View Full Text

Footnotes

  • Sources of funding: Department of Veterans Affairs Office of Research and Development and Dupont Pharmaceuticals.

  • For correspondence: Dr J H Krystal, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA.john.krystal{at}yale.edu.

  • Abstract and commentary also appear in Evidence-Based Mental Health.

  • * See glossary.

  • Information provided by author.