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Case report
Recurrent severe respiratory infections with low CRP secondary to autoimmune IL-6 deficiency
  1. Alexander Hackney,
  2. Sunil James and
  3. Surendra Karanam
  1. Department of Immunology, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK
  1. Correspondence to Dr Sunil James; sunil.james1{at}nhs.net

Abstract

C reactive protein (CRP) is an inflammatory protein that is often used in conjunction with the clinical presentation of a patient to help with quantifying infection severity and measuring treatment response. We report the case of a patient who presented with severe pneumonias but had a suboptimal CRP response, later diagnosed as having an underlying immunodeficiency. This case exemplifies the need to consider immunodeficiency as an underlying pathophysiological cause in patients presenting with complicated and severe infections.

  • immunological products and vaccines
  • infections
  • immunology

https://doi.org/10.1136/bcr-2021-243334

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    Footnotes

    • Contributors AH and SJ drafted the original paper. SK edited and finalised the paper.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.