Background Systemic lupus erythematosus - SLE is a chronic autoimmune disease characterized by the involvement of many organs. Fundamental principle of treatment of SLE is a comprehensive and individualized treatment approach, taking into account the duration and severity of the organ damage. Because of systemic, chronic, progressive course SLE adversely affects the physical functioning of patients, as well as it decreases their mental and social condition in effect of QOL lowering.

Objectives The aim of our work was to identify physical social, and psychological problems in patients suffering from lupus; assessment of quality of life; also to determine the degree of acceptance of the disease.

Methods The study was conducted among patients with diagnosed, according to the grading criteria of ACR for SLE, on a total of 37 patients. The research method was a diagnostic based on the original questionnaire, Anxiety and Depression Scale - HADS (0-21pts), Acceptance of Illness Scale - AIS (8-40pts), Visual- Analogue Pain Assessment Scale VAS (0-100mm), Quality of Life questionnaire WHOQOL BREF Polish version (4-20pts).

Results Most health problems which created troubles in the subjective assessment of respondents were: fatigue and weakness (91.9%), arthralgia and myalgia (81%), reduced resistance to illnesses (67.5%). Respondents inactive (1/3 of respondents) felt stronger pain (VAS ≥70mm). Patients with disease duration 0-5 years obtained a greater number of points in the HADS-D scale (mean 6.3) (p≤0.05) and inactive professionals in HADS-A scale (9.2) (p≤0.05). Patients with low education obtained higher value of the HADS-A and HADS-D (p≤0.05). Persons married also received higher scores at HADS-A (8.1) (p≤0.05). Patients with primary education/professional reported the worst acceptance of the disease (AIS - 19.5) (p≤0.05). People diagnosed with the disease at a younger age, single and with short duration of SLE (0-5 years) evaluated their worse functioning in all areas of QOL. The population of respondents with primary education/professional assessed the physical (9.1) and psychological (10.7) realm very low.

Conclusions The most nagging health problem reported by respondents was fatigue and weakness, joint and muscle pain, and low resistance to illnesses. Pain intensity (VAS) depended on patient's age and activity. The suspicion of existence of anxiety disorders (HADS-A) was observed more frequently in married and inactive patients. Respondents from all areas rated their physical and mental functioning lowest. Patients with short duration of SLE, alone, as well as with primary education/professional rated lowest their functioning in all areas of QOL.

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.1374