Tissue Affinity and Bioabsorption to Fine Calcium Carbonate Particles

Tetsunari NISHIKAWA; Tomoharu OKAMURA; Kazuya TOMINAGA; Masahiro WATO; Kagami KURIOKA; Shosuke MORITA; Koichi IMAI; Tatsuro MIYAKE; Akio TANAKA

doi:10.11344/nano.7.21

ORIGINAL ARTICLES

Tissue Affinity and Bioabsorption to Fine Calcium Carbonate Particles

Tetsunari NISHIKAWA, Tomoharu OKAMURA, Kazuya TOMINAGA, Masahiro WATO, Kagami KURIOKA, Shosuke MORITA, Koichi IMAI, Tatsuro MIYAKE, Akio TANAKA

Author information

Tetsunari NISHIKAWA
Department of Oral Pathology,
Tomoharu OKAMURA
Department of Oral Pathology,
Kazuya TOMINAGA
Department of Oral Pathology,
Masahiro WATO
Department of Oral Pathology,
Kagami KURIOKA
First Department of Oral and Maxillofacial Surgery,
Shosuke MORITA
First Department of Oral and Maxillofacial Surgery,
Koichi IMAI
Department of Biomaterials, Osaka Dental University, Osaka, Japan
Tatsuro MIYAKE
Department of Oral Health Sciences, Faculty of Nursing and Health Care, Baika Women's University, Osaka, Japan
Akio TANAKA
Department of Oral Pathology,

Keywords: bioabsorption, lymphocytes, macrophages, calcium particles

JOURNAL FREE ACCESS

2015 Volume 7 Issue 1 Pages 21-27

DOI https://doi.org/10.11344/nano.7.21

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Abstract

The scaffold material for the bone formation in the defect must be bioabsorptive. The calcium mineral of the scaffold is used for newly formed bone. In this study, we clarified the tissue affinity and bioabsorption to three kinds of novel fine calcium carbonate particles, LUMINUS, CUBE-18BH and WHISCAL. These particles were added into cell culture, and the mitochondrial activity of culture cell was calculated. These particles were then implanted under the dorsal skin of the rats, and were histopathologically observed.Five days after addition of the particles, there was no decrease in the mitochondrial activity. The implanted particles had completely disappeared with macrophages, without neutrophils. These kinds of fine calcium carbonate particles were bioabsorbable materials with few inflammatory reactions and were thought to be a useful scaffold for bone formation.

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