Skip to main content
SpringerLink
Log in

Recent Advances on Pyrazole-Pyrimidine/Fused Pyrimidine Hybrids with Anticancer Potential (A Review)

  • Published:
Russian Journal of General Chemistry Aims and scope Submit manuscript

Abstract

Cancer, caused by the failure of the mechanism that controls cell growth and proliferation, is usually associated with severe health issues. Nowadays, chemotherapy still occupies an important place in clinical cancer treatment, but the multidrug resistance and low specificity of chemotherapeutics are the major obstacles that undermine effective cancer treatment. Pyrazole and pyrimidine/fused pyrimidine can be rewarded with significant anticancer activity and tampered with in a range of places whereby some of their derivatives have received approval to treat cancer. Notably, pyrazole-pyrimidine/fused pyrimidine hybrids, blending of pyrazole and pyrimidine/fused pyrimidine pharmacophores into in a new chemical entity, can act on different targets simultaneously in cancer cells and possess potent in vitro and in vivo activity against both drug-sensitive and drug-resistant cancers. Moreover, several pyrazole-pyrimidine/fused pyrimidine hybrids which are exemplified by ruxolitinib (pyrazole-pyrrolo[2,3-d]pyrimidine hybrid) have already applied in clinics for cancer therapy, demonstrating pyrazole-pyrimidine/fused pyrimidine hybrids are pharmacologically significant scaffolds for the exploration of novel anticancer agents. This review aims to shed light on the recent developments of pyrazole-pyrimidine/fused pyrimidine hybrids with anticancer potential, and their structure-activity relationships as well as mechanisms of action are also discussed, covering papers published from 2019 to present, to facilitate further rational design of more effective candidates.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme
Scheme
Scheme
Scheme
Scheme
Scheme
Scheme
Scheme
Scheme
Scheme
Scheme

REFERENCES

  1. Hulvat, M.C., Surg. Clin. N. Am., 2020, vol. 100, p. 469. https://doi.org/10.1016/j.suc.2020.01.002

    Article  PubMed  Google Scholar 

  2. Ganini, C., Amelio, I., Bertolo, R., Bove, P., Buonomo, O.C., Candi, E., Cipriani, C., Wang, Y., and Melino, G., Mol. Oncol., 2021, vol. 15, p. 2823. https://doi.org/10.1002/1878-0261.13056

    Article  PubMed  PubMed Central  Google Scholar 

  3. Li, J., Wang, R., and Gao, J., Drug Discov. Ther., 2021, vol. 15, p. 44. https://doi.org/10.5582/ddt.2021.01013

    Article  CAS  PubMed  Google Scholar 

  4. Ioele, G., Chieffallo, M., Occhiuzzi, M.A., De Luca, M., Garofalo, A., Ragno, G., and Grande, F., Molecules, 2022, vol. 27, p. 5436. https://doi.org/10.3390/molecules27175436

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Emran, T.B., Shahriar, A., Mahmud, A.R., Rahman, T., Abir, M.H., Siddiquee, M.F.R., Ahmed, H., Islam, A., and Hassan, M.M., Front. Oncol., 2022, vol. 12, p. 891652. https://doi.org/10.3389/fonc.2022.891652

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Padma, P., Nandhakumar, R., and Smiline, G., Int. J. Pharm. Res., 2020, vol. 12, p. 1536. https://doi.org/10.1016/j.canlet.2014.03.013

    Article  CAS  Google Scholar 

  7. Dorbabu, A., Arch. Pharm., 2023, vol. 356, p. e2200562. https://doi.org/10.1002/ardp.202200562

  8. El-Gamal, M.I., Zaraei, S.O., Madkour, M.M., and Anbar, H. S., Molecules, 2022, vol. 27, p. 330. https://doi.org/10.3390/molecules27010330

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. He, Z.X., Zhao, T.Q., Gong, Y.P., Zhang, X., Ma, L.Y., and Liu, H.M., Eur. J. Med. Chem., 2020, vol. 200, p. 112458. https://doi.org/10.1016/j.ejmech.2020.112458

    Article  CAS  PubMed  Google Scholar 

  10. Rani, I., Kaur, N., Goyal, A., and Sharma, M., Anti-Cancer Agents Med. Chem., 2023, vol. 23, p. 525. https://doi.org/10.2174/1871520622666220701113204

    Article  CAS  Google Scholar 

  11. Haider, K., Das, S., Joseph, A., and Yar, M.S., Drug Dev. Res., 2022, vol. 83, p. 859. https://doi.org/10.1002/ddr.21925

    Article  CAS  PubMed  Google Scholar 

  12. Chen, X.B., Wang, S.Q., Wang, S., Yu, B., Yuan, X.H., and Zhao, W., Eur. J. Med. Chem., 2021, vol. 214, p. 113218. https://doi.org/10.1016/j.ejmech.2021.113218

    Article  CAS  PubMed  Google Scholar 

  13. Singh, A. K., Kumar, A., Singh, H., Sonawane, P., Paliwal, H., Thareja, S., Pathak, P., Khalilullah, H., and Kumar, P., Pharmaceuticals, 2022, vol. 15, p. 1071. https://doi.org/10.3390/ph15091071

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Soltan, O.M., Shoman, M.E., Abdel-Aziz, S.A., Narumi, A., Konno, H., and Abdel-Aziz, M., Eur. J. Med. Chem., 2021, vol. 225, p. 113768. https://doi.org/10.1016/j.ejmech.2021.113768

    Article  CAS  PubMed  Google Scholar 

  15. Szumilak, M., Wiktorowska-Owczarek, A., and Stanczak, A., Molecules, 2021, vol. 26, p. 2601. https://doi.org/10.3390/molecules26092601

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Rao, C.P.K., Rao, Charan, G.K., Srinu, B., and Maturi, S.R., Russ. J. Gen. Chem., 2019, vol. 89, p. 1023. https://doi.org/10.1134/S1070363219050244

    Article  Google Scholar 

  17. Yang, T., Hu, M., Qi, W., Yang, Z., Tang, M., He, J., Chen, Y., Xiang, M., and Chen, L. J. Med. Chem., 2019, vol. 62, p. 10305. https://doi.org/10.1021/acs.jmedchem.9b01348

    Article  CAS  PubMed  Google Scholar 

  18. Yang, T., Hu, M., Chen, Y., Xiang, M., Tang, M., Qi, W., Shi, M., Yang, Z., and Chen, L., J. Med. Chem., 2020, vol. 63, p. 14921. https://doi.org/10.1021/acs.jmedchem.0c01488

    Article  CAS  PubMed  Google Scholar 

  19. Mettu, A., Talla, V., Bajaj, D.M., and Subhashini, N.J.P., Arch. Pharm., 2019, vol. 352, p. e1900063. https://doi.org/10.1002/ardp.201900063

  20. Abdelgawad, M.A., Al-Sanea, M.M., Al-Warhi, T.I.M., Bakr, R.B., Elshemy, H.A.H., Elsherif, H.A.M., Gamal, M., Parambi, D.G.T., and Shaker, M.E., Russ. J. Org. Chem., 2020, vol. 56, p. 514. https://doi.org/10.1134/S1070428020030239

    Article  Google Scholar 

  21. Mettu, A., Talla, V., and Naikal, S.J.P., Bioorg. Med. Chem. Lett., 2020, vol. 30, p. 127470. https://doi.org/10.1016/j.bmcl.2020.127470

    Article  CAS  PubMed  Google Scholar 

  22. Zhang, Z., Guo, Z., Xu, X., Cao, D., Yang, H., Li, Y., Shi, Q., Huang, X., and Xiong, B., J. Med. Chem., 2021, vol. 64, p. 16650. https://doi.org/10.1021/acs.jmedchem.1c01308

    Article  CAS  PubMed  Google Scholar 

  23. Tong, L., Song, P., Jiang, K., Xu, L., Jin, T., Wang, P., Hu, X., Li, J., and Hu, Y., Eur. J. Med. Chem., 2019, vol. 173, p. 44. https://doi.org/10.1016/j.ejmech.2019.03.062

    Article  CAS  PubMed  Google Scholar 

  24. Kuriwaki, I., Kameda, M., Iikubo, K., Hisamichi, H., Kawamoto, Y., Kikuchi, S., Moritomo, H., Kikuchi, A., and Hirano, M., Bioorg. Med. Chem., 2022, vol. 59, p. 116657. https://doi.org/10.1016/j.bmc.2022.116657

    Article  CAS  PubMed  Google Scholar 

  25. Futami, T., Kawase, T., Mori, K., Asaumi, M., Kihara, R., Shindoh, N., and Kuromitsu, S., Sci. Rep., 2019, vol. 9, p. 14627. https://doi.org/10.1038/s41598-019-51217-6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Yamamoto, N., Ryoo, B.Y., Keam, B., Kudo, M., Lin, C.C., Kunieda, F., Ball, H.A., Morita, S., and Doi, T., Invest. New Drugs, 2020, vol. 38, p. 445. https://doi.org/10.1007/s10637-019-00780-w

    Article  CAS  PubMed  Google Scholar 

  27. Liang, X., Zang, J., Li, X., Tang, S., Huang, M., Geng, M., Chou, C. J., Liu, H., and Zhang, Y., J. Med. Chem., 2019, vol. 62, p. 3898. https://doi.org/10.1021/acs.jmedchem.8b01597

    Article  CAS  PubMed  Google Scholar 

  28. Zhang, L., Moccia, M., Briggs, D.C., Bharate, J.B., Lakkaniga, N.R., Knowles, P., Yan, W., Carlomagno, F., and Li, H.Y., J. Med. Chem., 2022, vol. 65, p. 1536. https://doi.org/10.1021/acs.jmedchem.1c01280

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Brawn, R.A., Cook, A., Omoto, K., Ke, J., Karr, C., Colombo, F., Virrankoski, M., Zhao, X., and Ioannidis, S., ACS Med. Chem. Lett., 2021, vol. 12, p. 93. https://doi.org/10.1021/acsmedchemlett.0c00517

    Article  CAS  PubMed  Google Scholar 

  30. Gunasekaran, P., Yim, M.S., Ahn, M., Soung, N.K., Park, J.E., Kim, J., Bang, G., Ryu, E.K., and Bang, J.K., J. Med. Chem., 2020, vol. 63, p. 14905. https://doi.org/10.1021/acs.jmedchem.0c01451

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Finlay, M.R.V., Barton, P., Bickerton, S., Bista, M., Colclough, N., Cross, D.A.E., Evans, L., Ye, Y., and Zhao, X., J. Med. Chem., 2021, vol. 64, p. 13704. https://doi.org/10.1021/acs.jmedchem.1c01055

    Article  CAS  PubMed  Google Scholar 

  32. Fang, H., Wu, Y., Xiao, Q., He, D., Zhou, T., Liu, W., Yang, C. H., and Xie, Y., Bioorg. Med. Chem. Lett., 2022, vol. 72, p. 128729. https://doi.org/10.1016/j.bmcl.2022.128729

    Article  CAS  PubMed  Google Scholar 

  33. Huang, D., Yang, J., Zhang, Q., Wang, G., Zhang, Z., Zhang, Y., and Li, J., Eur. J. Med. Chem., 2021, vol. 223, p. 113648. https://doi.org/10.1016/j.ejmech.2021.113648

    Article  CAS  PubMed  Google Scholar 

  34. Vurucu, B., Mert, S., Koldaş, S., Demirtaş, İ., and Kasımoğulları, R., J. Iran. Chem. Soc., 2023, vol. 20, p. 1107. https://doi.org/10.1007/s13738-022-02738-x

    Article  CAS  Google Scholar 

  35. Zhang, J.J., Zhang, W., Zhang, L., Hu, M., Xu, Q.J., and Xu, Y., Bioorg. Med. Chem., 2022, vol. 74, p. 117051. https://doi.org/10.1016/j.bmc.2022.117051

    Article  CAS  PubMed  Google Scholar 

  36. Liang, X., Tang, S., Liu, X., Liu, Y., Xu, Q., Wang, X., Saidahmatov, A., Huang, M., and Liu, H., J. Med. Chem., 2022, vol. 65, p. 1243. https://doi.org/10.1021/acs.jmedchem.0c02111

    Article  CAS  PubMed  Google Scholar 

  37. Wang, R., Zhao, X., Yu, S., Chen, Y., Cui, H., Wu, T., Hao, C., Zhao, D., and Cheng, M., Bioorg. Chem., 2020, vol. 102, p. 104092. https://doi.org/10.1016/j.bioorg.2020.104092

    Article  CAS  PubMed  Google Scholar 

  38. Tian, L., Li, X., Lv, Z., Yang, Y., Wang, L., Xu, D., Ma, X., and Xu, Y., Bioorg. Med. Chem., 2022, vol. 74, p. 117052. https://doi.org/10.2147/DDDT.S351049

    Article  CAS  PubMed  Google Scholar 

  39. Lakkaniga, N.R., Gunaganti, N., Zhang, L., Belachew, B., Frett, B., Leung, Y.K., and Li, H.Y., Eur. J. Med. Chem., 2020, vol. 206, p. 112691. https://doi.org/10.1016/j.bmc.2022.117052

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Gong, Y., Wu, F.X., Wang, M.S., Xu, H.C., Zhuo, L.S., Yang, G.F., and Huang, W., Eur. J. Med. Chem., 2022, vol. 241, p. 114654. https://doi.org/10.1016/j.ejmech.2022.114654

    Article  CAS  PubMed  Google Scholar 

  41. Zhuo, L.S., Wang, M.S., Wu, F.X., Xu, H.C., Gong, Y., Yu, Z.C., Tian, Y.G., Huang, W., and Yang, G.F., J. Med. Chem., 2021, vol. 64, p. 15503.

    Article  CAS  PubMed  Google Scholar 

  42. Ali, G.M.E., Ibrahim, D.A., Elmetwali, A.M., and Ismail, N.S.M., Bioorg. Chem., 2019, vol. 86, p. 1. https://doi.org/10.1016/j.bioorg.2019.01.008

    Article  CAS  PubMed  Google Scholar 

  43. Berger, B.T., Celik, I.E., Greco, F.A., Hanke, T., Knapp, S., Krämer, A., Kurz, C.G., and Tjaden, A., Eur. J. Med. Chem., 2020, vol. 208, p. 112770. https://doi.org/10.1016/j.ejmech.2020.112770

    Article  CAS  PubMed  Google Scholar 

  44. Fathy, U., Abu-Hashem, A.A., Gouhar, R.S., Awad, H.M., and Elgamal, A.M., Rasayan J. Chem., 2021, vol. 14, p. 741. https://doi.org/10.31788/RJC.2021.1426137

    Article  CAS  Google Scholar 

  45. Fouda, A.M., Abbas, H.A.S., Ahmed, E.H., Shati, A.A., Alfaifi, M.Y., and Elbehairi, S.E.I., Molecules, 2019, vol. 24, p. 1080. https://doi.org/10.3390/molecules24061080

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Fayed, E.A., Gohar, N.A., Bayoumi, A.H., and Ammar, Y.A., Med. Chem. Res., 2023, vol. 32, p. 369. https://doi.org/10.1007/s00044-022-03004-8

    Article  CAS  Google Scholar 

  47. Fayed, E.A., Eissa, S.I., Bayoumi, A.H., Gohar, N.A., Mehany, A.B.M., and Ammar, Y.A., Mol. Diversity, 2019, vol. 23, p. 165. https://doi.org/10.1007/s11030-018-9865-9

    Article  CAS  Google Scholar 

  48. Hassan, M.H.A., Kamel, G., Khedr, M.A., Lamie, P.F., and Philoppes, J.N., Bioorg. Chem., 2020, vol. 100, p. 103944. https://doi.org/10.1016/j.bioorg.2020.103944

    Article  CAS  PubMed  Google Scholar 

  49. Hosny, M.A., Zaki, Y.H., Mokbel, W.A., and Abdelhamid, A.O., Med. Chem., 2020, vol. 16, p. 750. https://doi.org/10.2174/1573406415666190620144404

    Article  CAS  PubMed  Google Scholar 

  50. Farghaly, T.A., Abdulwahab, H.G., Medrasi, H.Y., Al-sheikh, M.A., Katowah, D.F., and Alsaedi, A.M.R., Bioorg. Chem., 2022, vol. 128, p. 106043. https://doi.org/10.1016/j.bioorg.2022.106043

    Article  CAS  PubMed  Google Scholar 

  51. Arafa, R.K., Maher, A., Nissan, Y.M., Ragab, F.A., and Seif, E.M., Bioorg. Chem., 2020, vol. 96, p. 103621. https://doi.org/10.1016/j.bioorg.2020.103621

    Article  CAS  PubMed  Google Scholar 

  52. Massaro, M., Barone, G., Barra, V., Cancemi, P., Leonardo, A.D., Grossi, G., Celso, F.L., Schenone, S., Iborra, C.V., and Riela, S., Int. J. Pharm., 2021, vol. 599, p. 120281. https://doi.org/10.1016/j.ijpharm.2021.120281

    Article  CAS  PubMed  Google Scholar 

  53. Muthuraja, P., Veeramani, V., Prakash, S., Himesh, M., Venkatasubramanian, U., and Manisankar, P., Bioorg. Chem., 2019, vol. 84, p. 493. https://doi.org/10.1016/j.bioorg.2018.12.014

    Article  CAS  PubMed  Google Scholar 

  54. Gaonkar, S., Savanur, M.A., Nadaf, A.A., Najare, M.S., Mantur, S., Garbhagudi, M., Mulla, S.I., and Khazi, I.A.M., Arch. Pharm., 2020, vol. 353, p. e1900296. https://doi.org/10.1002/ardp.201900296

  55. Abulkhair, H.S., Al-Karmalawy, A.A., Bayoumi, A.H., El-Adl, K., El-Gamal, K.M., El-Morsy, A.M., Ezz-Eldin, R.R., Gaber, A.A., Saleh, M.A., and Sherbiny, F.F., Arch. Pharm., 2021, p. e2100258. https://doi.org/10.1002/ardp.202100258

  56. Horchani, M., Sala, G.D., Caso, A., Daria, F., Esposito, G., Laurenzana, I., Giancola, C., Costantino, V., Jannet, H.B., and Romdhane, A., Int. J. Mol. Sci., 2021, vol. 22, p. 2742. https://doi.org/10.3390/ijms22052742

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Cacciari, B., Romagnoli, R., Romani, A., Trentini, A., and Hanau, S., Future Med. Chem., 2021, vol. 13, p. 1515. https://doi.org/10.4155/fmc-2021-0131

    Article  CAS  PubMed  Google Scholar 

  58. Yin, Y., Chen, C.J., Yu, R.N., Shu, L., Zhang, T.T., and Zhang, D.Y., Bioorg. Med. Chem., 2019, vol. 27, p. 1562. https://doi.org/10.1016/j.bmc.2019.02.054

    Article  CAS  PubMed  Google Scholar 

  59. Valero, T., Baillache, D.J., Fraser, C., Myers, S.H., and Unciti-Broceta, A., Bioorg. Med. Chem., 2020, vol. 28, p. 115215. https://doi.org/10.1016/j.bmc.2019.115215

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Radini, I.A.M., Acta Pol. Pharm., 2021, vol. 78, p. 71. https://doi.org/10.32383/appdr/133242

    Article  CAS  Google Scholar 

  61. Dong, J., Zhu, X., Yu, W., Hu, X., Zhang, Y., Yang, K., You, Z., Liu, Z., Qiao, X., and Song, Y., J. Mol. Struct., 2023, vol. 1272, p. 134221. https://doi.org/10.1016/j.molstruc.2022.134221

    Article  CAS  Google Scholar 

  62. Ruzi, Z., Bozorov, K., Nie, L., Zhao, J., and Aisa, H.A., Biomed. Pharmacother., 2022, vol. 156, p. 113948. https://doi.org/10.1016/j.biopha.2022.113948

    Article  CAS  PubMed  Google Scholar 

  63. Mandour, A.A., Nassar, I.F., Aal, M.T.A., Shahin, A.A.E., El-Sayed, W.A., Hegazy, M., Yehia, A.M., Ismail, A., Hagras, M., Elkaeed, E.B., Refaat, H.M., and Ismail, N.S.M., J. Enzym. Inhib. Med. Chem., 2022, vol. 37, p. 1957. https://doi.org/10.1080/14756366.2022.2086866

    Article  CAS  Google Scholar 

  64. Zheng, Y.G., Pei, X., Xia, D.X., Wang, Y.B., Jiang, P., An, L., Huang, T.H., and Xue, Y.S., Bioorg. Chem., 2021, vol. 109, p. 104711. https://doi.org/10.1016/j.bioorg.2021.104711

    Article  CAS  PubMed  Google Scholar 

  65. Horchani, M., Heise, N.V., Hoenke, S., Csuk, R., Harrath, A.H., Jannet, H.B., and Romdhane, A., Int. J. Mol. Sci., 2021, vol. 22, p. 10258. https://doi.org/10.3390/ijms221910258

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Afifi, O.S., Shaaban, O.G., Abd El Razik, H.A., Shams El-Dine, S.E.D.A., Ashour, F.A., El-Tombary, A.A., and Abu-Serie, M.M., Bioorg. Chem., 2019, vol. 87, p. 821. https://doi.org/10.1016/j.bioorg.2019.03.076

    Article  CAS  PubMed  Google Scholar 

  67. Degorce, S.L., Anjum, R., Bloecher, A., Carbajo, R.J., Dillman, K.S., Drew, L., Halsall, C.T., Scott, J.S., and Xue, Y., J. Med. Chem., 2019, vol. 62, p. 9918. https://doi.org/10.1021/acs.jmedchem.9b01346

    Article  CAS  PubMed  Google Scholar 

  68. Abdelaziz, O.A., El-Husseiny, W.M., Selim, K.B., and Eisa, H.M., Bioorg. Chem., 2019, vol. 90, p. 103076. https://doi.org/10.1016/j.bioorg.2019.103076

    Article  CAS  PubMed  Google Scholar 

  69. Ran, K., Zeng, J., Wan, G., He, X., Feng, Z., Xiang, W., Wei, W., Liu, Z., and Yu, L., Eur. J. Med. Chem., 2021, vol. 220, p. 113499. https://doi.org/10.1016/j.ejmech.2021.113499

    Article  CAS  PubMed  Google Scholar 

  70. Gorle, S., Gangu, K.K., Maddila, S., and Jonnalagadda, S.B., Chem. Data Collect., 2020, vol. 28, p. 100471. https://doi.org/10.1016/j.cdc.2020.100471

    Article  CAS  Google Scholar 

  71. El-Gohary, N.S., Hawas, S.S., Gabr, M.T., Shaaban, M.I., and El-Ashmawy, M.B., Bioorg. Chem., 2019, vol. 92, p. 103109. https://doi.org/10.1016/j.bioorg.2019.103109

    Article  CAS  PubMed  Google Scholar 

  72. Liu, K.G., Kim, J.I., Olszewski, K., Barsotti, A.M., Morris, K., Lamarque, C., Yu, X., Patel, J.P., and Poyurovsky, M.V., J. Med. Chem., 2020, vol. 63, p. 5201. https://doi.org/10.1021/acs.jmedchem.9b02153

    Article  CAS  PubMed  Google Scholar 

  73. Kim, N., Shin, I., Lee, J., Jeon, E., Kim, Y., Ryu, S., Ju, E., Cho, W., and Sim, T., Int. J. Mol. Sci., 2021, vol. 22, p. 3783. https://doi.org/10.3390/ijms22073783

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Pan, S., Zhang, L., Luo, X., Nan, J., Yang, W., Bin, H., Li, Y., Li, L., and Yang, S., J. Med. Chem., 2022, vol. 65, p. 2035. https://doi.org/10.1021/acs.jmedchem.1c01597

    Article  CAS  PubMed  Google Scholar 

  75. Huo, J.L., Wang, S., Yuan, X.H., Yu, B., Zhao, W., and Liu, H.M., Eur. J. Med. Chem., 2021, vol. 211, p. 113108. https://doi.org/10.1016/j.ejmech.2020.113108

    Article  CAS  PubMed  Google Scholar 

  76. Bagal, S.K., Gregson, C., O’Donovan, D.H., Pike, K.G., Bloecher, A., Barton, P., Borodovsky, A., Woods, H., and Williamson, B., J. Med. Chem., 2021, vol. 64, p. 17146. https://doi.org/10.1021/acs.jmedchem.1c01161

    Article  CAS  PubMed  Google Scholar 

  77. Halim, K.N.M., Rizk, S.A., El-Hashash, M.A., and Ramadan, S.K., J. Heterocyclic Chem., 2021, vol. 58, p. 636. https://doi.org/10.1002/jhet.4204

    Article  CAS  Google Scholar 

  78. Pogaku, V., Krishnan, R., and Basavoju, S., Res. Chem. Intermed., 2021, vol. 47, p. 551. https://doi.org/10.1007/s11164-020-04285-7

    Article  CAS  Google Scholar 

  79. Li, Y., Yang, G., Zhang, J., Tang, P., Yang, C., Wang, G., Chen, J., Liu, J., Zhang, L., and Ouyang, L., J. Med. Chem., 2021, vol. 64, p. 12022. https://doi.org/10.1021/acs.jmedchem.1c00678

    Article  CAS  PubMed  Google Scholar 

  80. Yan, W., Zhang, L., Lv, F., Moccia, M., Carlomagno, F., Landry, C., Santoro, M., Gosselet, F., Frett, B., and Li, H.Y., Eur. J. Med. Chem., 2021, vol. 216, p. 113265. https://doi.org/10.1016/j.ejmech.2021.113265

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Medicine, Sun Yat-sen University, 518107, Shenzhen, China

    Sicheng Wang

  2. Department of Nephrology, The Third Clinical Medical College of the Three Gorges University, Gezhouba Central Hospital of Sinopharm, 443002, Yichang, China

    Senlin Qian

  3. Department of Clinical Laboratory, The Third Clinical Medical College of the Three Gorges University, Gezhouba Central Hospital of Sinopharm, 443002, Yichang, China

    Sheng Wang

  4. The Third Clinical Medical College of China Three Gorges University, Gezhouba Central Hospital of Sinopharm, 443002, Yichang, China

    Yulin Zou

Authors
  1. Sicheng Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Senlin Qian
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sheng Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yulin Zou
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yulin Zou.

Ethics declarations

The authors declared no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, S., Qian, S., Wang, S. et al. Recent Advances on Pyrazole-Pyrimidine/Fused Pyrimidine Hybrids with Anticancer Potential (A Review). Russ J Gen Chem 93, 2090–2112 (2023). https://doi.org/10.1134/S1070363223080194

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1070363223080194

Keywords:

Search

Navigation