Abstract
Complexation in the systems Pd(II)-Cl−-HA-H2Glu (HA is the l- or d-conformer of 2-methylamino-1-phenylpropanol; H2Glu is glutamic acid) was studied using pH-metric titration, electronic absorption spectroscopy, and quantum-chemical modeling. It was found that the ratio of the complex species largely depends on pH and the amine, the crucial factor being stabilization of the structures by hydrogen bonding. This provides explanation to the previous data on the different radioprotective activities of the complexes (H2A)2[PdCl4] containing the l- and d-conformers of the ligand HA.
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Original Russian Text © I.A. Efimenko, N.A. Dobrynina, O.N. Shishilov, N.A. Ivanova, O.S. Erofeeva, 2012, published in Koordinatsionnaya Khimiya, 2012, Vol. 38, No. 4, pp. 243–250.
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Efimenko, I.A., Dobrynina, N.A., Shishilov, O.N. et al. Reactions of the biologically active palladium complexes (H2A)2[PdCl4] with glutamic acid as a model of their transformations in blood plasma. Russ J Coord Chem 38, 233–239 (2012). https://doi.org/10.1134/S1070328412020029
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DOI: https://doi.org/10.1134/S1070328412020029