Nerve deafness is assumed to accompany more or less disturbance of metabolism in sensory tissue of inner ear, and dispensation of ferments ought to be useful to promote it in the treatment. The present writers injected 80 cases with the mixture of V. B1 (50mg/day) and V. B6 (20mg/day) every day for 15 to 90 days, and compared the results of audiometry before and after the treat-ment. The insufflation was applied at thh same time.
The effect was measured at low frequency and high frequency on 146 ears.
The total ratio of efficacy was 50. 7% (74 ears). Concerning tinitis and vertigo, the ratio was 46.3% (38 ears) and 76. 5% (13 ears) respectively.
The relationship between the duration of disease and the efficiency of treatment was as fol-lows:
On cases of deafness, the efficacy ratio was 54. 1% when treated within 1 year of the beginning of disease, and 32. 4% within 1 to 5 years. More than half of the improved ears were within 1 year, and after 5 years of duration of disease the efficacy ratio was as small as 13. 5%. On cases of tinitis and vertigo, the ratio was 66. 8% and 75% respectively within 1 year of the beginning of disease, almost no effect was proved on the cases after 5 years of duration, which fact may be accounted for by a little restorability of ganglion cells. Regarding the relation of diagnostics and the efficiency of treatment, more efficacy was achieved in cases of sudden deafness, Meniere's disease and some of unaccountable nerve deafness, when they begrn to be treated comparatively early. More than half of the improved ears showed improvement at low frequency, which fact may be said to suggest the susceptibility of cochlear turns of inner ear.