サルにおけるカナマイシン聴器毒性に対するセファランチンの効果
1989 年 20 巻 1 号 p. 81-82
詳細
1989 年 20 巻 1 号 p. 81-82
Protective effect of cepharanthine against ototoxicity induced by Kanamycin was investigated in monkey.
KM was injected intramusculary at 200mg/kg continuously for 28 days, and cepharanthine was injected intramusculary at 1mg/kg and 5mg/kg simultaneously with KM.
Cochlear damage was studied by ABR and SEM. The cochlear damage of monkey administered both KM and cepharanthine was more severe than that of monkey administered KM only.
But presuming by the changes of body weight, the result might be strongly affected by indivisual difference of nephrotoxicity.
