Pharmacokinetics of Digitalis in Some Domestic Animals

Yoshimichi MIYAZAWA; Tomohide SATO; Hideo MIYASHITA

doi:10.11276/jsvc1984.21.1

Yoshimichi MIYAZAWA, Tomohide SATO, Hideo MIYASHITA

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JOURNAL FREE ACCESS

1988 Volume 21 Issue 21 Pages 1-19

DOI https://doi.org/10.11276/jsvc1984.21.1

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Published: 1988 Received: - Available on J-STAGE: March 05, 2010 Accepted: - Advance online publication: - Revised: -
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Date of correction: March 05, 2010 Reason for correction: - Correction: CITATION Details: Wrong : 1) DETWEILER, D. K.(1965): Cardiac glycosides in the treatment of congestive heart failure in dogs. J. Am. Anim. Hosp. Assoc., 1, 29-34
2) DEAR, M. G. (1979) : Agents acting on the cardiovascular system. II. Clinical use in small animals. In Pharmacological Basis of Small Animal Medicine. YOXALL, A. T. . and HIRD, J. F. R. editors, pp. 63-84, Blackwell Scientific Publications, Oxford.
3) DETWEILER, D. K.(1977): Cardiac drugs. In Veterinary Pharmacology and Therapeutics. 4th ed., JONES, L.M., BOOTH, N.H. and MCDONALD, L. E. editors, pp. 496-542, The Iowa State Universiy Press/AMES.
4) ADAMS, H. R.(1982) : Digitalis and other inotropic agents. In Veterinary Pharmacology and Therapeutics. 5th ed., BOOTH, N. H. and McDONALD, L. E. editors, pp. 435-457, The Iowa State University Press/AMES.
5) HAMLIN, R. L.(1978): Basis for selection of cardiac glycoside for dogs. Proc. 1 st Symp. Vet. Pharmacol. Therap., pp. 241-261.
6) MILLER, M. S. (1985) : Digitalis : Current concepts and clinical usage in small animals. Canine Prac., 12, 6-16.
7) JENKINS, W. L. and CLARK, D. R.(1977) : A review of drugs affecting the heart. J. Am. Vet. Med. Assoc., 171, 85-92.
8) KAUFMAN, G.M. and WEIRICH, W.E.(1983) : Oral cardiac glycoside therapy in the dog. Comb. Cont. Ed. 5 753-760_
12) HERRMANN, R.G., PARKER, R.J., HENDERSON, F. G. and CHEN, K. K. (1962):Intestinal absorption of cardiac steroids. Proc. Soc. Exp. Biol. Med., 109, 646-649.
13) BREZNOCK, E. M. (1973) : Application of canine plasma kinetics of digoxin and digitoxin to therapeutic digitalization in the dog. Am. J. Vet. Res., 34, 993-999.
14) KRASULA, R. W., GARDELLA, L. A., ZAROSLINSKI ,J. F. and MORRIS, R.N.(1976): Comparative bioavailability of four dosage forms of digoxin in dogs. Fed. Proc., 35, 327.
15) GHIRARDI, P., CATENAZZO, G., MANTERO, O, MEROTTI, G. C. and MARZO, A. (1977) : Bioavailability of digoxin in a new soluble pharmaceutical formulation in capsules. J. Pharm. Sci., 66, 267-269. 16) DERICK, A., CHAKRABARTI, S., BELPAIRE, F. and BOGAERT, M.(1979): Bioavailability of three brands of digoxin tablets in dogs. J. Vet. Pharmacol. Therap. 2, 27-29.
17) BUTTON, C., GROSS, D. R., JOHNSTON, J. T. and YAKATAN, G. J.(1980): Pharmacokinetics, bioavailability, and dosage regimens of digoxin in dogs. Am. J. Vet. Res., 41, 1230-1237.
18) BUTTON, C., GROSS, D.R., and ALLERT J,A, (1980): Application of individualized digoxin dosage regimens to canine therapeutic digitalization Am, J, Vet. Res., 41, 1238-1242.
19) PEDERSOLI. W. M, (1978) : Serum digoxin concentrations in healthy dogs treated without a loading dose. J. Vet. Pharmacol. Therap., 1, 279-284.
21) ERICHSEN, D. F., HARRIS, S. G. and UPSON, D. W. (1978): Plasma levels of digoxin in the cat: some clinical applications. J. Am. Anim. Hosp. Assoc., 14, 734-737.
22) LAHRTZ, H., SATTLER, R.W. and VAN ZWIETEN, P.A.(1968) : Uber den Blutspiegel and die Ausschidung radioaktiv markierter Herzglykoside nach deren intraduodenaler Applikation bei der Katze. Z. Gesamte Exp. Med., 148, 210-222.
23) BUTTON. C., GROSS, D.R., JOHNSTON, J.T. and YAKATAN G. J. (1980): Digoxin pharmacokinetics, bioavailability, efficacy, and dosage regimens in the horse. Am. J. Vet. Res., 41, 1388-1395.
24) PEDERSOLI, W. M., BELMONTE, A. A., PUROHIT, R. C. and NACHREINER, R. F.(1978): Pharmacokinetics of digoxin in the horse. J. Equine Med., Surgery, 2, 384-388.
25) PEDERSOLI,W. M., RAMS, W.R., BELMONTE A. A. and MCCULLERS, R. M.(1981): Pharmacokinetics of a single, orally administered dose of digoxin in horses. Am. J. Vet. Res., 42, 1412-1414.
26) BRUMBAUGH, G.W., THOMAS, W.P., ENOS, L. R, and KANEKO, J. J. (1983) : A pharmacokinetic study of digoxin in the horse. J. Vet. Pharmacol. Therap., 6, 163-172.
27) WESTERMARCK, H. (1959) : Digitalis] inactivation in vitro due to rumen microbes from sheep. Acta Vet. Scand., 1, 67-73.
29) BAGGOT, J. D. and DAVis, L. E. (1973): Plasma protein binding of digitoxin and digoxin in several mammalian species. Res. Vet. Sci., 15, 81-87.
30) GIBSON, T. P. and QUINTANILLA, A.(1980): Effect of quinidine on the renal handlig of digoxin. J. Lab. Clin. Med., 96, 1062-1070.
31) SCHAUMANN, W. and KOCH, K.(1974) : β-methyl-digoxin. VII. Tissue distribution, positive inotropic and central action in cats in comparison with other digitalis glycosides. Naunyn-Schmiedeberg's Arch. Pharmacol., 286, 195-210.
32) BERMAM, W. Jr. and MUSSELMAN, J.(1979): The relationship of age to the metabolism and protein binding of digoxin in sheep. J. Pharmacol. Exp. Ther., 208, 263-266.
33) FRANCFORT, P. and SCHATZMANN, H. J. (1976): Pharmacological experiments as a basis for the administration of digoxin in the horse. Res. Vet. Sci., 20, 84-89.
34) DOHERTY, J. E. and PERKINS, W. H.(1966): Tissue concentration and turnover of tritiated digoxin in dogs. Am. J. Cardiol., 17, 47-52.
35) BREZNOCK, E. M.(1975): Effects of phenobarbital on digitoxin and digoxin elimination in the dog. Am. J. Vet. Res., 36, 371-373.
36) DERICK, A., BELPAIRE, F. M., BOGAERT, M.G. and MATTHEEUWS, D. (1978): Plasma concentrations of digoxin and digitoxin during digitalization of healthy dogs and dogs with cardiac failure. Am. J. Vet. Res., 39, 811-815.
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38) BARR, I., SMITH, T. W., KLEIN, M. D., HAGEMEIJER, F. and LOWN, B.(1972): Correlation of the electrophysiologic action of digoxin with serum digoxin concentration. J. Pharmacol. Exp. Ther., 180, 710-722.
39) GIERKE, K. D., PERRIER, D., MAYERSOHN M. and MARCUS, F.I.(1978): Digoxin disposition kinetics in dogs before and during azotemia. J. Pharmacol. Exp. Ther., 205, 459-464.
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41) KALMAN, S. M., GijLLNER, H. G., GIBSON, Th. A., KUHN, S., STINSON, E.B., MILLER, R. and HALPERN J., (1980) : A two-compartment model for digoxin disposition in dogs. Arzneim. -Forsch., 30, 943-945.
42) GIBSON, T. P. and NELSON, H. A. (1980): Digoxin alters quinidine and quinidine alters digoxin pharmacokinetics in dogs. J. Lab. Clin. Med., 95, 417-428.
43) BUTTON, C. and GROSS, D. R. (1980) : A pharmacokinetic basis for the administration of digoxin to puppies. J. Vet. Pharmacol. Therap., 3, 209-215.
44) WILKERSON, R. D., MOCKRIDGE, P. B. and MASSING, G.K.(1980): Effects of selected drugs on serum digoxin concentration in dogs. Am. J. Cardiol., 45, 1201-1210.
46) RAVIS, W.R., PEDERSOLI, W.M. and TURCO, J.D. (1987): Pharmacokinetics and interactions of digoxin with phenobarbital in dogs. Am. J. Vet. Res., 48, 1244-1249.
47) BLUSCHKE, V. and VIANA, A. P. (1976) : Digitoxin plasma half-life in the dog after administration of toxic doses. Arzneim.-Forsch., 26, 591-592.
48) KATZUNG, B. G. and MEYERS, F. H.(1965): Excretion of radioactive digitoxin by the dog. J. Pharmacol. Exp. Ther., 149, 257-262.
49) GREEFF, K., G., GREVEN, OSSWALD, W. and VIANA, A.P.(1969): Studies on the elimination of digitoxin and ouabain in the dog, using the tolerance test of repeated intravenous infusions. Arch. Int. Pharmacodyn., 179, 326-335.
50) AMLIE, J.P., STORSTEIN, L. and HELDAAS O. (1979) : Correlation between pharmacokinetics and inotropic and electrophysiologic responses to digitoxin in the intact dog. J. Cardiovasc. Pharmacol., 1, 529-540.
51) SHAH, G., NELSON, H. A., ATKINSON, A. J. Jr., OKITA, G.T., IVANOVICH, P. and GIBSON, T.P.(1979): Effect of hemoperfusion on the pharmacokinetics of digitoxin in dogs. J. Lab. Clin. Med., 93, 370-380.
52) PETERS, D. N., HAMLIN, L. R. and POWERS J. D. (1981): Absence of pharmacokinetic interaction between digitoxin and quinidine in the dog. J. Vet. Pharmacol. Therap., 4, 271-275.
54) MIYAZAWA, Y. (1987) : Plasma and tissue radioactivity of 3H-digitoxin in dogs with experimental acute renal failure. Jpn. J. Vet. Sci., 49, 859-866.
55) SELDEN, R. and SMITH, T. W.(1972): Ouabain pharmacokinetics in dog and man: Determination by radioimmunoassay. Circulation 45, 1176-1182.
56) GLANTZ, S., KERNOFF, A. R. and GOLDMAN R. H. (1976): Age-related changes in ouabain pharmacology: Ouabain exhibits a different volume of distribution in adult and young dogs. Cir. Res., 39, 407-414.
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59) HEINZ, N. and FLASCH, H.(1978): Comparison of the pharmacokinetics of digoxin and dihydrodigoxin in cats in single-dose studies. Naunyn-Schmiedeberg's Arch. Pharmacol., 303, 181-187.
60) WEIDLER, D. J., JALLAD, N. S., MOVAHHED, H.S., SAKMAR, E. and WAGNER, J. G.(1978): Pharmacokinetics of digoxin in the cat and comparisons with man and the dog. Res. Commun. Chem. Pathol. Pharmacol., 19, 57-66.
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62) BAUER, I., NEUBERT, P. and SCHAUMANN, W. (1987): Pharmacodynamics, pharmacokinetics and metabolism of digitoxin and derivatives in cats. Naunyn-Schmiedeberg's Arch. Pharmcol., 335, 469-475.
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66) DEEGEN, E., SCHMIDT-RIMPLER, K. and LIESKE, R. (1979): Untersuchungen zur Blutplasmakonzentration and Vertraglichkeit von p-Methyl-Digoxin beim Pferd. Dtsch. Tierarztl. Wschr., 86, 88-94.
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72) MARCUS, F. I., PAVLOVICH, J., BURKHALTER, L. and CUCCIA, C.(1967): The metabolic fate of tritiated digoxin in the dog: A comparison of digitalis administration with and without a “loading dose”. J. Pharmacol. Exp. Ther., 156, 548-556.
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86) St. GEORGE, S., BINE, R. Jr., FRIEDMAN, M., and BLAND, C. (1951) : Renal excretion of digitoxin in the rabbit and dog. Proc. Soc. Exp. Med., 78, 504-505.
87) ST. GEORGE, S,. BINE, R. Jr. and FRIEDMAN, M.(1952): Role of the liver in excretion and destruction of digitoxin. Circualtion, 6, 661-665.
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92) DERICK, A. and BELPAIRE, F.(1981): Digoxin-quinidine interaction in the dog. J. Vet. Pharmacol. Therap., 4, 215-218.
93) ROUGEOT, C., JOZEFCZAK, C., MESTRE, M., LEFUR, G. and UZAN, A.(1984): PK 10139 and quinidine: interactions with digoxin concentrations in rats and dogs. J. Pharm. Pharmacol., 36, 347-949.
94) WILKERSON, R. D. and BECK B. L. (1987): Increase in serum digoxin concentration produced by quinidine dose not increase the potential for digoxin induced ventricular arrhythmias in dogs. J. Pharmacol. Exp. Ther., 240, 548-553.
95) WARNER, N. J., LEAHE Y,E.B.Jr., HOUGEN, T. J., BIGGER, J. T. Jr, and SMITH, T. W. (1983): Tissue digoxin concentrations during the quinidine-digoxin interaction. Am. J. Cardiol., 51, 1717-1721.
96) PEDERSOLI, W.M., RAVIS, W.R. and NACHREINER, R.F. (1983): Serum digoxin concentrations in healthy dogs before, during, and after concomitant treatment with furosemide, hydrochlorthiazide, and phenytoin. J. Am. Anim. Hosp. Assoc., 19, 1031-1036.
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100) STEINESS, E.(1978): Digoxin toxicity compared with myocardial digoxin and potassium concentration. Br. J. Pharmacol., 63, 233-237.
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102) GIBSON, T. P. and QUINTANILLA, A. P. (1980): Effect of volume expansion and furosemide diuresis on the renal clearance of digoxin. J. Pharmacol. Exp. Ther., 219, 54-59.
103) WILKERSON, R. D.(1981): Acute effects of intravenous furosemide administration on serum digoxin concentration. Am. Heart J., 102, 63-65.
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Right : 1) DETWEILER, D. K.(1965): Cardiac glycosides in the treatment of congestive heart failure in dogs. J. Am. Anim. Hosp. Assoc., 1, 29-34
2) DEAR, M. G. (1979) : Agents acting on the cardiovascular system. II. Clinical use in small animals. In Pharmacological Basis of Small Animal Medicine. YOXALL, A. T. . and HIRD, J. F. R. editors, pp. 63-84, Blackwell Scientific Publications, Oxford.
3) DETWEILER, D. K.(1977): Cardiac drugs. In Veterinary Pharmacology and Therapeutics. 4th ed., JONES, L.M., BOOTH, N.H. and MCDONALD, L. E. editors, pp. 496-542, The Iowa State Universiy Press/AMES.
4) ADAMS, H. R.(1982) : Digitalis and other inotropic agents. In Veterinary Pharmacology and Therapeutics. 5th ed., BOOTH, N. H. and McDONALD, L. E. editors, pp. 435-457, The Iowa State University Press/AMES.
5) HAMLIN, R. L.(1978): Basis for selection of cardiac glycoside for dogs. Proc. 1 st Symp. Vet. Pharmacol. Therap., pp. 241-261.
6) MILLER, M. S. (1985) : Digitalis : Current concepts and clinical usage in small animals. Canine Prac., 12, 6-16.
7) JENKINS, W. L. and CLARK, D. R.(1977) : A review of drugs affecting the heart. J. Am. Vet. Med. Assoc., 171, 85-92.
8) KAUFMAN, G.M. and WEIRICH, W.E.(1983) : Oral cardiac glycoside therapy in the dog. Comb. Cont. Ed. 5 753-760_
12) HERRMANN, R.G., PARKER, R.J., HENDERSON, F. G. and CHEN, K. K. (1962):Intestinal absorption of cardiac steroids. Proc. Soc. Exp. Biol. Med., 109, 646-649.
13) BREZNOCK, E. M. (1973) : Application of canine plasma kinetics of digoxin and digitoxin to therapeutic digitalization in the dog. Am. J. Vet. Res., 34, 993-999.
14) KRASULA, R. W., GARDELLA, L. A., ZAROSLINSKI ,J. F. and MORRIS, R.N.(1976): Comparative bioavailability of four dosage forms of digoxin in dogs. Fed. Proc., 35, 327.
15) GHIRARDI, P., CATENAZZO, G., MANTERO, O, MEROTTI, G. C. and MARZO, A. (1977) : Bioavailability of digoxin in a new soluble pharmaceutical formulation in capsules. J. Pharm. Sci., 66, 267-269.
16) DERICK, A., CHAKRABARTI, S., BELPAIRE, F. and BOGAERT, M.(1979): Bioavailability of three brands of digoxin tablets in dogs. J. Vet. Pharmacol. Therap. 2, 27-29.
17) BUTTON, C., GROSS, D. R., JOHNSTON, J. T. and YAKATAN, G. J.(1980): Pharmacokinetics, bioavailability, and dosage regimens of digoxin in dogs. Am. J. Vet. Res., 41, 1230-1237.
18) BUTTON, C., GROSS, D.R., and ALLERT J,A, (1980): Application of individualized digoxin dosage regimens to canine therapeutic digitalization Am, J, Vet. Res., 41, 1238-1242.
19) PEDERSOLI. W. M, (1978) : Serum digoxin concentrations in healthy dogs treated without a loading dose. J. Vet. Pharmacol. Therap., 1, 279-284.
21) ERICHSEN, D. F., HARRIS, S. G. and UPSON, D. W. (1978): Plasma levels of digoxin in the cat: some clinical applications. J. Am. Anim. Hosp. Assoc., 14, 734-737.
22) LAHRTZ, H., SATTLER, R.W. and VAN ZWIETEN, P.A.(1968) : Uber den Blutspiegel and die Ausschidung radioaktiv markierter Herzglykoside nach deren intraduodenaler Applikation bei der Katze. Z. Gesamte Exp. Med., 148, 210-222.
23) BUTTON. C., GROSS, D.R., JOHNSTON, J.T. and YAKATAN G. J. (1980): Digoxin pharmacokinetics, bioavailability, efficacy, and dosage regimens in the horse. Am. J. Vet. Res., 41, 1388-1395.
24) PEDERSOLI, W. M., BELMONTE, A. A., PUROHIT, R. C. and NACHREINER, R. F.(1978): Pharmacokinetics of digoxin in the horse. J. Equine Med., Surgery, 2, 384-388.
25) PEDERSOLI,W. M., RAMS, W.R., BELMONTE A. A. and MCCULLERS, R. M.(1981): Pharmacokinetics of a single, orally administered dose of digoxin in horses. Am. J. Vet. Res., 42, 1412-1414.
26) BRUMBAUGH, G.W., THOMAS, W.P., ENOS, L. R, and KANEKO, J. J. (1983) : A pharmacokinetic study of digoxin in the horse. J. Vet. Pharmacol. Therap., 6, 163-172.
27) WESTERMARCK, H. (1959) : Digitalis] inactivation in vitro due to rumen microbes from sheep. Acta Vet. Scand., 1, 67-73.
29) BAGGOT, J. D. and DAVis, L. E. (1973): Plasma protein binding of digitoxin and digoxin in several mammalian species. Res. Vet. Sci., 15, 81-87.
30) GIBSON, T. P. and QUINTANILLA, A.(1980): Effect of quinidine on the renal handlig of digoxin. J. Lab. Clin. Med., 96, 1062-1070.
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