Original paper

Massive bone destruction in a human proximal femur from ancient Nubia

Buzon, Michele R.; Loder, Randall T.; Joseph, Benjamin; Whitmore, Katie M.

Anthropologischer Anzeiger Volume 81 No. 1 (2024), p. 51 - 59

published: Jan 25, 2024
published online: Jul 28, 2023
manuscript accepted: May 25, 2023
manuscript revision received: May 22, 2023
manuscript revision requested: Feb 14, 2022
manuscript received: Dec 21, 2022

DOI: 10.1127/anthranz/2023/1700

BibTeX file

ArtNo. ESP140008101005, Price: 29.00 €

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Abstract

Massive bone destruction in a human right proximal femur is described and differentially discussed in this case study. The individual was an older adult female buried at the ancient Nubian site of Tombos (modern-day Sudan) dating to the early Napatan/Third Intermediate Period (c. 1069-750 BCE). The right femur displayed a pathologic fracture with extensive lytic destruction and resorption of the entire femoral neck, most of the femoral head, and trochanters. Macroscopic and radiographic analyses revealed cortical thinning of the proximal diaphysis with new bone formation enclosing the medullary cavity. The lesion is eccentrically located involving the anterior aspect of the neck. Numerous vascular channels are apparent in the underlying bone. Sclerotic bone marks the limit of the lesion, and osseous lucency is visible in the radiograph. The individual displayed no other lytic lesions; vertebral osteophytic growth, compression fractures, and Schmorl’s nodes were observed along with dental disease typical for older individuals. A traumatic etiology is eliminated due to the extensive osteolysis. Vascular, congenital, and developmental conditions are also not consistent with the observed changes. Expansive osteolytic lesions may have been caused by a cyst. Neoplastic tumors resulting in lytic lesions with a high risk of pathologic fracture are also consistent. There have been few reports of such extensive lytic lesions of the proximal femur in the paleopathological and clinical literature; this case adds an example of this underreported condition.

Keywords

lytic lesion • cyst • neoplasm • pathological fracture • early Napatan/Third Intermediate Period • Tombos • Sudan