Ticarcillin was administered at a daily dose of 2-12 g for 8-38 days to 15 cases of acute exacerbation of chronic bronchitis complicated with chronic panbronchiolitis.
As to the global effects classified by causative organism, 12 cases of Ps. aerugionosa resulted in excellent effect in 3 cases, good effect in 3 cases, and no effect in 6 cases, and 2 cases of Klebsiella and 1 case of Enterobacter excellent effect. As to the effects classified by dose, cases ofPs. aeruginosa (majority of the cases) resulted in no effect in all 3 cases at a daily dose of 2-3 g, while no effect in 1 case out of 9 cases at a dose of more than 4 g. Ticarcillin should be administered thus at a daily dose of more than 4 g, more than 10 g if possible, to chronic bronchitis complicated with chronic panbronchiolitis due to Pseudomonas.
As for the side effect of the antibiotic, no finding was found by ticarcillin administration except that a transient eosinophilia was noticed in 1 case.