1973 年 21 巻 2 号 p. 313-316
Sulfamethoxazole-trimethoprim combination product was used orally 4-8 tablets daily for 5-67 days, in 10 patients (empyema 1, pneumonia 2, acute pharyngitis 1, co-infection of pulmonary tuberculosis 1, lymphadenitis colli simplex 1, chronic pyelonephritis 1, cholecystitis 2, typhoid fever carrier 1).
(1) The results were excellent in 1 patient (empyema), good in 6 patients, fair in 1 patient (typhoid fever carrier), poor in 1 patient (lymphadenitis colli simplex) and uncertain (because of simultaneous use of CET) in 1 patient (pnenumonia).
(2) Side effects were observed in 4 patients, nausea 1, poor appetite 1, glossitis 1, skin rush, fever and iridocyclitis (maybe the side effects of sulfamethoxazole) 1.
(3) Two patients showed leucopenia, one became soon normal after the finish of the treatment, another became also normal in spite of using the drugs.
(4) No disturbance of liver and renal function was detected.