Doxycycline(Vibramycin): (each capsule contains 100 mg potency) was orally administered in order to determine its blood and urine concentrations. Then the drug was given to 34 patients with various urological infections to evaluate the clinical effectiveness.
The results are summarized as follows.
1. After oral administration of doxycycline 100 mg, the blood concentration reached to the peak (0. 83 mcg/ml) in 4 hours, and the blood concentration after 24 hours was 0. 22 mcg/ml.
2. After oral administration of doxycycline 100 mg, the urinary concentration was the highest during 6 to 8 hours.
3. In 34 patients with various urological infections who were treated with doxycycline, excellent, marked and no effects were obtained in 7, 17 and 10 cases respectively, with the effectiveness being 69. 1%. 4. The most remarkable effect was observed in acute cases, although some effects were expectable even in chronic cases.
5. The drug was most effective against Staphylococcal infections. The effectiveness against E. coil infection was recorded as 72. 4% which was also remarkable.