Abstract: In Thailand, road traffic accidents cause more than 14,000 deaths annually. Human factors were the major contributor for most traffic accident. In order to prevent such losses, the concise information set for decision-making traffic planners and road safety administrator has to be done. This paper detailed some of the findings of an Injury Surveillance system, coupled with a Geographic Information System based information system for analyzing causes of road traffic accident in Khon Kaen municipality. Four major types of analysis were developed, 1) factors contributing to traffic accident, 2) trend of hazardous intersection, 3) trend of hazardous road section, 4) comparison of traffic accidents on arterial and collector. We included the importance of local conditions and human error, and the multidisciplinary approached for the 5 E strategies (Engineering, Enforcement, Education, Emergency Medical Service, and Empowerment).