Photopatternable hydrogel materials for reversible optical hydrogen peroxide and glucose sensors

C. Pick; M. Boresi; C. Kim; D. Henthorn

doi:10.1117/12.818816

24 April 2009 Photopatternable hydrogel materials for reversible optical hydrogen peroxide and glucose sensors

C. Pick, M. Boresi, C. Kim, D. Henthorn

Proceedings Volume 7313, Smart Biomedical and Physiological Sensor Technology VI; 73130A (2009) https://doi.org/10.1117/12.818816
Event: SPIE Defense, Security, and Sensing, 2009, Orlando, Florida, United States

Abstract

In this work, a novel photopatternable hydrogel-based material for the fluorescent detection of hydrogen peroxide was developed and studied as a possible sensing element in optical biosensors. This composite hydrogel material was developed to maximize analyte transport, be amenable to existing microfabrication techniques, and dovetail with various enzyme immobilization strategies. Nanoparticles loaded with a hydrogen peroxide sensitive europium tetracycline complex (EuTc) were mixed with monomer and crosslinker to form a photopolymerizable precursor. Sensitivity to glucose can be introduced through addition of methacrylated glucose oxidase into the precursor solution, allowing for covalent immobilization of the enzyme. As a result, the material can be integrated directly into optical biosensors for continuous glucose monitoring.

Citation Download Citation

C. Pick, M. Boresi, C. Kim, and D. Henthorn "Photopatternable hydrogel materials for reversible optical hydrogen peroxide and glucose sensors", Proc. SPIE 7313, Smart Biomedical and Physiological Sensor Technology VI, 73130A (24 April 2009); https://doi.org/10.1117/12.818816

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KEYWORDS

Silica

Hydrogen

Glucose

Sensors

Luminescence

Polymers

Oxygen

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