In vivo on-line monitoring of molecular response to photodynamic therapy: molecular imaging of vascular endothelial growth factor

Sung K. Chang; Imran Rizvi; Nicolas Solban; Tayyaba Hasan

doi:10.1117/12.706605

8 March 2007 In vivo, on-line monitoring of molecular response to photodynamic therapy: molecular imaging of vascular endothelial growth factor

Sung K. Chang, Imran Rizvi, Nicolas Solban, Tayyaba Hasan

Author Affiliations +

Proceedings Volume 6427, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI; 64270P (2007) https://doi.org/10.1117/12.706605
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Cytokines are important messengers in cell-to-cell communications that regulate vital cellular and physiological processes, and play an important role in defining the diagnosis, prognosis and treatment response in various diseases. Although current ex vivo biochemical assays for cytokine quantitation are useful, their capabilities for studying dynamic cytokine expression in living systems are limited. Optical molecular imaging technology can help probe the spatiotemporal dynamics of cytokine expression in vivo and in real-time. We developed an in vivo optical molecular imaging strategy for monitoring one of these cytokines, the vascular endothelial growth factor (VEGF). With the imaging strategy, changes in tumoral VEGF concentration following cobalt chloride treatment and photodynamic therapy (PDT) were monitored. This was the first systematic study to test the feasibility of VEGF-targeted molecular imaging, and can potentially set the basis for online monitoring of cytokines that will help develop effective tools for diagnosis, prognosis, treatment planning and monitoring.

Citation Download Citation

Sung K. Chang, Imran Rizvi, Nicolas Solban, and Tayyaba Hasan "In vivo, on-line monitoring of molecular response to photodynamic therapy: molecular imaging of vascular endothelial growth factor", Proc. SPIE 6427, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI, 64270P (8 March 2007); https://doi.org/10.1117/12.706605

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KEYWORDS

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Molecular imaging

In vivo imaging

Photodynamic therapy

Cancer

Cobalt

Luminescence

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