Experimental and theoretical studies of dual energy subtraction angiography (DESA) performed using laser-based x-ray source

Andrzej Krol; Jean-Claude Kieffer; Zahia Ichalalene; Zhiming Jiang; Charles C. Chamberlain; Ernest M. Scalzetti

doi:10.1117/12.448470

14 November 2001 Experimental and theoretical studies of dual energy subtraction angiography (DESA) performed using laser-based x-ray source

Andrzej Krol, Jean-Claude Kieffer, Zahia Ichalalene, Zhiming Jiang, Charles C. Chamberlain, Ernest M. Scalzetti

Author Affiliations +

Proceedings Volume 4504, Applications of X Rays Generated from Lasers and Other Bright Sources II; (2001) https://doi.org/10.1117/12.448470
Event: International Symposium on Optical Science and Technology, 2001, San Diego, CA, United States

Abstract

Two types of x-ray sources for dual energy subtraction angiography (DESA), laser-based and conventional, were investigated. A Tabletop Terawatt laser was used to create x-ray source with Ba, La, Nd, Gd, and Ce targets. A theoretical model of image quality was developed. A Figure of Merit, FOM equals SNR./(integral dose)1/2, was obtained. Images of an angiographic contrast detail phantom were obtained using laser-driven x-ray source in DESA regime and a standard angiography unit in DSA regime. The log-signals due to Iodine contrast agent in the images were measured and compared with the theoretical model predictions. The integral dose was estimated. We found that the La and Ba lines extracted by a monochromator are optimal for imaging Iodine contrast with laser-based DESA. In this case, SNR exhibits three- to five-fold improvement, as compared to SNR expected for a tube-based DESA system. Consequently, dose utilization, as defined by FOM, improves by factor of two to three, depending on patient thickness and scatter conditions. When only filters are used, SNR and FOM due to laser-based system are comparable to those due to tube-based DESA. In this case, preferable target/filter combination for the laser system is Ba/I and Ce/Nd for the low- and high-beam, respectively.

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Andrzej Krol, Jean-Claude Kieffer, Zahia Ichalalene, Zhiming Jiang, Charles C. Chamberlain, and Ernest M. Scalzetti "Experimental and theoretical studies of dual energy subtraction angiography (DESA) performed using laser-based x-ray source", Proc. SPIE 4504, Applications of X Rays Generated from Lasers and Other Bright Sources II, (14 November 2001); https://doi.org/10.1117/12.448470

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