Development of an optical polarimeter for in-vivo glucose monitoring

Brent D. Cameron; Harshal Gorde; Gerard L. Cote

doi:10.1117/12.348370

17 May 1999 Development of an optical polarimeter for in-vivo glucose monitoring

Brent D. Cameron, Harshal Gorde, Gerard L. Cote

Proceedings Volume 3599, Optical Diagnostics of Biological Fluids IV; (1999) https://doi.org/10.1117/12.348370
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

In our investigation, we present both multi-spectral in vitro and preliminary single wavelength in vivo results supporting the use of optical polarimetry as a potential non-invasive method for glucose sensing. The site utilized for our in vivo measurements is the anterior chamber of the eye in a rabbit model. The anterior chamber of the eye contains a relatively clear and minimal scattering fluid known as the aqueous humor. The glucose levels of the aqueous humor are correlated to those of blood, therefore providing a mechanism to indirectly estimate blood glucose levels. A device to effectively couple light through the anterior chamber is also presented. As for the in vitro experiments, a multi-spectral approach is demonstrated as a method to minimize prediction error when glucose is not the only optically active component that varies in concentration.

Citation Download Citation

Brent D. Cameron, Harshal Gorde, and Gerard L. Cote "Development of an optical polarimeter for in-vivo glucose monitoring", Proc. SPIE 3599, Optical Diagnostics of Biological Fluids IV, (17 May 1999); https://doi.org/10.1117/12.348370

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