Three-dimensional characterization of murine ovary elasticity using quantitative micro-elastography.

Matt Hepburn; Anna Jaeschke; Alireza Mowla; Chii J. Chan; Brendan F. Kennedy

doi:10.1117/12.3006718

13 March 2024 Three-dimensional characterization of murine ovary elasticity using quantitative micro-elastography.

Matt Hepburn, Anna Jaeschke, Alireza Mowla, Chii J. Chan, Brendan F. Kennedy

Proceedings Volume PC12844, Optical Elastography and Tissue Biomechanics XI; PC128440B (2024) https://doi.org/10.1117/12.3006718
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Tissue elasticity regulates the reproductive function of the mammalian ovary. However, characterizing micro-scale elasticity of entire intact ovaries in three-dimensions (3-D) remains challenging. This limits our ability to study how the elasticity of different ovarian structures, such a follicles, oocytes, and corpus luteum, as well as the entire ovary, affect ovarian function. In this work, for the first time, we extend quantitative micro-elastography to characterize 3-D micro-scale elasticity of entire murine ovaries. We demonstrate distinct elasticity patterns of key ovarian structures as well as changes in tissue elasticity with age.

Conference Presentation

Citation Download Citation

Matt Hepburn, Anna Jaeschke, Alireza Mowla, Chii J. Chan, and Brendan F. Kennedy "Three-dimensional characterization of murine ovary elasticity using quantitative micro-elastography.", Proc. SPIE PC12844, Optical Elastography and Tissue Biomechanics XI, PC128440B (13 March 2024); https://doi.org/10.1117/12.3006718

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