All-optical phase retrieval microscope designed using differentiable microscopy

Kithmini Herath; Udith Haputhanthri; Ramith Hettiarachchi; Hasindu Kariyawasam; Raja N. Ahmad; Azeem Ahmad; Balpreet S. Ahluwalia; Chamira U. S. Edussooriya; Dushan N. Wadduwage

doi:10.1117/12.3002933

13 March 2024 All-optical phase retrieval microscope designed using differentiable microscopy

Kithmini Herath, Udith Haputhanthri, Ramith Hettiarachchi, Hasindu Kariyawasam, Raja N. Ahmad, Azeem Ahmad, Balpreet S. Ahluwalia, Chamira U. S. Edussooriya, Dushan N. Wadduwage

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Proceedings Volume PC12857, Computational Optical Imaging and Artificial Intelligence in Biomedical Sciences; PC128570P (2024) https://doi.org/10.1117/12.3002933
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

With applications in quantitative metabolomics and label-free digital pathology, Quantitative Phase Microscopy (QPM) measures refractive index maps of thin transparent specimens like live cells or tissue sections. In QPM, refractive index maps are usually reconstructed from interference measurements of the object’s light field with respect to a reference field. To this end, many previous works focused on designing stable full-field interferometers from the bottom up. In this work, we present an alternative strategy to design a QPM system top-down, starting from the desired measurement outcomes, with no explicit knowledge about interferometry. We call our inverse design strategy Differentiable Microcopy. To this end, our Differentiable Microcopy approach designed a range of Fourier-filter-based QPM systems that do not require computational post-reconstruction. Our designs are superior to existing similar designs in numerical benchmarks. We also experimentally validated one design using a spatial light modulator. Finally, to fabricate these custom designs in the future, we also propose a new fabrication-aware Differentiable Microcopy pipeline.

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Kithmini Herath, Udith Haputhanthri, Ramith Hettiarachchi, Hasindu Kariyawasam, Raja N. Ahmad, Azeem Ahmad, Balpreet S. Ahluwalia, Chamira U. S. Edussooriya, and Dushan N. Wadduwage "All-optical phase retrieval microscope designed using differentiable microscopy", Proc. SPIE PC12857, Computational Optical Imaging and Artificial Intelligence in Biomedical Sciences, PC128570P (13 March 2024); https://doi.org/10.1117/12.3002933

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KEYWORDS

Design and modelling

Microscopy

Imaging systems

Education and training

Fabrication

Optical design

Interferometry

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