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19 March 2024 Miniaturised 3D printed fibre-optic probe for autofluorescence detection of human plaques
Rouyan Chen, Florian Rothermel, Andrea Toulouse, Philipp Flad, Robert Fitridge, Robert A. McLaughlin, Harald Giessen, Alois M. Herkommer, Jiawen Li
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Proceedings Volume PC12820, Endoscopic Microscopy XIX; PC128200A (2024) https://doi.org/10.1117/12.3002467
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Atherosclerosis is characterised by the buildup of plaque in the inner lining of vessels. Unstable atherosclerotic plaques are prone to rupture, which can lead to heart attacks or strokes. Current clinically available imaging techniques cannot accurately identify unstable plaques based on their structural features. It has been previously reported that unstable plaques may emit autofluorescence. Therefore, our team has developed a dual modality optical coherence tomography and fluorescence intravascular imaging system, and a miniaturised fibre-optic probe incorporating a 3D printed lens. The 3D printed lens is designed to correct the astigmatism that arises from the intravascular catheter, and to reduce stray light. Although the 3D printed lens is made by a polymer photoresist, it has low background fluorescence. We are using our novel fibre probe to explore the autofluorescence present in unstable human plaques.
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Rouyan Chen, Florian Rothermel, Andrea Toulouse, Philipp Flad, Robert Fitridge, Robert A. McLaughlin, Harald Giessen, Alois M. Herkommer, and Jiawen Li "Miniaturised 3D printed fibre-optic probe for autofluorescence detection of human plaques", Proc. SPIE PC12820, Endoscopic Microscopy XIX, PC128200A (19 March 2024); https://doi.org/10.1117/12.3002467
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KEYWORDS
3D printing
Atherosclerosis
Autofluorescence
Miniaturization
Optical coherence tomography
Fluorescence
Photoresist materials
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