Metasurface-enhanced nanospectroscopy and molecular diagnostics towards quantum biomedical engineering

Inki Kim

doi:10.1117/12.3000267

13 March 2024 Metasurface-enhanced nanospectroscopy and molecular diagnostics towards quantum biomedical engineering

Inki Kim

Proceedings Volume PC12863, Quantum Effects and Measurement Techniques in Biology and Biophotonics; PC128630S (2024) https://doi.org/10.1117/12.3000267
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

In this talk, I will introduce metasurface-enhanced multiplexed nanospectroscopy and molecular diagnostics. First, we report metasurfaces-driven hyperspectral imaging via multiplexed plasmon resonance energy transfer to probe biological light-matter interactions, which can detect quantum biological electron transfer. We conduct real-time and label-free monitoring of reactive oxygen species (ROS) from different types of cells. We used three different cells, normal cells, tumor cells, and drug-treated tumor cells, and quantitatively analyzed ROS production in real-time. Second, we scalably fabricate a low-power-consuming metaphotonic PCR device composed of a metamaterial perfect absorber that can rapidly go through thermocycling steps using a single infrared LED. We demonstrate an ultrafast photonic reverse transcription PCR (RT-PCR) with 30 thermocycles achieving 21.9 °Cs-1 heating rate and 7.8 °Cs-1 cooling rate. Furthermore, we would like to utilize the metaphotonic PCR chip for quantitative quantum enzymology.

Conference Presentation

Citation Download Citation

Inki Kim "Metasurface-enhanced nanospectroscopy and molecular diagnostics towards quantum biomedical engineering", Proc. SPIE PC12863, Quantum Effects and Measurement Techniques in Biology and Biophotonics, PC128630S (13 March 2024); https://doi.org/10.1117/12.3000267

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KEYWORDS

Diagnostics

Nanospectroscopy

Biomedical engineering

Biomedical optics

Design and modelling

Light-matter interactions

Multiplexing

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