The numerical model of Ca2+ nanospark in cardiac myocytes

Menghao Xu; Yongshen Liang

doi:10.1117/12.2685983

28 July 2023 The numerical model of Ca²⁺ nanospark in cardiac myocytes

Menghao Xu, Yongshen Liang

Proceedings Volume 12756, 3rd International Conference on Applied Mathematics, Modelling, and Intelligent Computing (CAMMIC 2023); 127562R (2023) https://doi.org/10.1117/12.2685983
Event: 2023 3rd International Conference on Applied Mathematics, Modelling and Intelligent Computing (CAMMIC 2023), 2023, Tangshan, China

Abstract

Given the importance of Ca²⁺ spark and Ca²⁺ nanospark and the lack of relevant simulation, the numerical model of Ca²⁺ nanospark is constructed in this paper. We constructed a kinetic model according to the physiological mechanism of Ca²⁺ nanospark and Ca²⁺ spark. Then, a geometric model is constructed for the occurrence space of Ca²⁺ nanospark and Ca²⁺ nanospark and a structured grid for it is generated. Finally, the numerical model of Ca²⁺ nanospark is constructed by using the finite difference method. We use the model to simulate the basic Ca²⁺ spark and Ca²⁺ nanospark, and the coincidence degrees of most temporal properties are about 90%. In addition, the numerical model can explore the corresponding kinetics changes of Ca²⁺ spark and Ca²⁺ nanospark by adjusting the model parameters.

Citation Download Citation

Menghao Xu and Yongshen Liang "The numerical model of Ca²⁺ nanospark in cardiac myocytes", Proc. SPIE 12756, 3rd International Conference on Applied Mathematics, Modelling, and Intelligent Computing (CAMMIC 2023), 127562R (28 July 2023); https://doi.org/10.1117/12.2685983

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available