Taper-in-taper fiber structure-based biosensor for diagnosis of kidney failure

Fei Liu; Ragini Singh; Bingyuan Zhang; Santosh Kumar

doi:10.1117/12.2682705

27 November 2023 Taper-in-taper fiber structure-based biosensor for diagnosis of kidney failure

Fei Liu, Ragini Singh, Bingyuan Zhang, Santosh Kumar

Proceedings Volume 12771, Advanced Sensor Systems and Applications XIII; 1277115 (2023) https://doi.org/10.1117/12.2682705
Event: SPIE/COS Photonics Asia, 2023, Beijing, China

Conference Poster

Abstract

Creatinine is a metabolite of human muscles that can be used to infer whether part of the kidneys is functioning properly. In this paper, a taper-in-taper fiber (TITF) based fiber optic biosensor is proposed for detecting the concentrations of creatinine solution and helps to diagnosis of kidney failure. The TITF structure used in this study is formed by fabricating a taper shape again in the tapered region of a normal taper optical fiber. This allows the fiber to produce more higher-order modes and thus improve its ability to sense changes in refractive index of the external environment. The sensitivity of the sensor was increased by coating the tapered region of the TITF fiber with a gold nanoparticles and zinc oxide nanomaterials. Creatinase enzyme is used to increase the specificity of the sensor for creatinine. The experimental results show that the sensor can detect the creatinine solution with the concentrations of 300-2000 μM and the sensitivity is 0.17 a.u./μM. It provides a good choice for biomedical applications.

(2023) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Fei Liu, Ragini Singh, Bingyuan Zhang, and Santosh Kumar "Taper-in-taper fiber structure-based biosensor for diagnosis of kidney failure", Proc. SPIE 12771, Advanced Sensor Systems and Applications XIII, 1277115 (27 November 2023); https://doi.org/10.1117/12.2682705

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