PROTACS: an emerging strategy for intracellular and integral membrane protein degradation

Yifan Huang; Hanxie Shen; Yu Sun

doi:10.1117/12.2669371

24 March 2023 PROTACS: an emerging strategy for intracellular and integral membrane protein degradation

Yifan Huang, Hanxie Shen, Yu Sun

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 1261152 (2023) https://doi.org/10.1117/12.2669371
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

A newly emerging technology, the ubiquitin-proteasome system (UPS), plays an important role in cancer treatment. Proteolysis targeting chimeras (PROTACs) is a system containing heterobifunctional small compounds which utilizes UPS to destroy proteins of interest (POI). Although the PROTAC method successfully breaks down intracellular proteins, it has recently been used to break down integral membrane proteins (IMPs). This review will cover the creation of the PROTACs approach based on cytoplasm and integral membrane protein targets, as well as a comparison of PROTACs and molecular glues, a cutting-edge technology for protein degradation.

Citation Download Citation

Yifan Huang, Hanxie Shen, and Yu Sun "PROTACS: an emerging strategy for intracellular and integral membrane protein degradation", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 1261152 (24 March 2023); https://doi.org/10.1117/12.2669371

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