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In this study, we propose a new approach to measuring tissue oxygenation with near-infrared spectroscopy using a single source-detector separation. This method is based on the difference in absorbance at three wavelengths before, at, and after the isosbestic point. The accuracy of tissue oxygenation measurement using the multiwavelength method was tested using Monte Carlo simulation and spatially resolved spectroscopy. Tissue oxygenation calculated from a single source-detector separation using multiwavelength was similar to one calculated from two source-detector separations using the spatially resolved method. This suggested method can help to simplify a tissue oximeter.
Thien Nguyen,Soongho Park,Brian Hill, andAmir Gandjbakhche
"Multiwavelength based approach to calculate tissue oxygen saturation using near-infrared spectroscopy", Proc. SPIE PC12375, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables IV, PC1237508 (6 March 2023); https://doi.org/10.1117/12.2661535
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Thien Nguyen, Soongho Park, Brian Hill, Amir Gandjbakhche, "Multiwavelength based approach to calculate tissue oxygen saturation using near-infrared spectroscopy," Proc. SPIE PC12375, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables IV, PC1237508 (6 March 2023); https://doi.org/10.1117/12.2661535