Multiphoton imaging in conjunction with ICG imaging by a rigid endomicroscope combined with laser ablation in the head and neck region

Chenting Lai; Bernhard Messerschmidt; Karl Reichwald; Sven Flämig; Tino Eidam; Fabian Stutzki; Matteo Calvarese; Hyeonsoo Bae; Tobias Meyer-Zedler; Michael Schmitt; Herbert Gross; Franziska Hoffmann; Orlando Guntinas-Lichius; Juergen Popp

doi:10.1117/12.2650213

25 April 2023 Multiphoton imaging in conjunction with ICG imaging by a rigid endomicroscope combined with laser ablation in the head and neck region

Chenting Lai, Bernhard Messerschmidt, Karl Reichwald, Sven Flämig, Tino Eidam, Fabian Stutzki, Matteo Calvarese, Hyeonsoo Bae, Tobias Meyer-Zedler, Michael Schmitt, Herbert Gross, Franziska Hoffmann, Orlando Guntinas-Lichius, Juergen Popp

Author Affiliations +

Proceedings Volume 12384, Multiphoton Microscopy in the Biomedical Sciences XXIII; 123840G (2023) https://doi.org/10.1117/12.2650213
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Here, we present a new handheld multiphoton endomicroscopic system designed for tumor diagnosis in the head and neck region. It consists of an approximate 25-cm-long rigid endomicroscopic probe with two variants (0° and 45° bended tip), connected to a handheld scan-head. The system can achieve a field of view ⪆600 µm for Coherent Anti-stokes Raman Scattering (CARS) and other nonlinear imaging modalities by a non-de-scanned detection and using a de-scanned confocal imaging channel to detect light from tissue labeled with Indocyanine Green (ICG). Furthermore, high-power femtosecond laser pulses can be transmitted through the system for precise tissue ablation which was considered in the optical design of the probe.

Conference Presentation

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Chenting Lai, Bernhard Messerschmidt, Karl Reichwald, Sven Flämig, Tino Eidam, Fabian Stutzki, Matteo Calvarese, Hyeonsoo Bae, Tobias Meyer-Zedler, Michael Schmitt, Herbert Gross, Franziska Hoffmann, Orlando Guntinas-Lichius, and Juergen Popp "Multiphoton imaging in conjunction with ICG imaging by a rigid endomicroscope combined with laser ablation in the head and neck region", Proc. SPIE 12384, Multiphoton Microscopy in the Biomedical Sciences XXIII, 123840G (25 April 2023); https://doi.org/10.1117/12.2650213

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