Identification of cardiac scar by extending multimodal optical imaging with multiparametric analysis and radiomics

Arno M. Krause; Gabriel Giardina; James Marchant; Richard Walton; Laszlo Papp; Rainer Leitgeb; Wolfgang Drexler; Angelika Unterhuber; Marco Andreana

doi:10.1117/12.2649151

6 March 2023 Identification of cardiac scar by extending multimodal optical imaging with multiparametric analysis and radiomics

Arno M. Krause, Gabriel Giardina, James Marchant, Richard Walton, Laszlo Papp, Rainer Leitgeb, Wolfgang Drexler, Angelika Unterhuber, Marco Andreana

Author Affiliations +

Proceedings Volume PC12371, Multimodal Biomedical Imaging XVIII; PC1237102 (2023) https://doi.org/10.1117/12.2649151
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Sudden cardiac death being the most likely reason of mortality in western countries is associated with preliminary occurring myocardial infarctions causing variations in structure, texture, metabolism and molecular composition. Common therapy methods lacking sufficient resolution for precise differentiation between fibrotic and physiological cardiac tissue. Novel multimodal diagnostic approaches are required and explored with our developed ultrahigh-resolution multimodal optical imaging platform including optical coherence tomography, multiphoton microscopy and line scan Raman spectroscopy in a label-free manner at cellular resolution. Co-registration of all modalities and integrated multiparametric analysis and radiomics provide complementary morphological, metabolic and molecular contrast for unprecedented cardiac tissue classification.

Conference Presentation

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Arno M. Krause, Gabriel Giardina, James Marchant, Richard Walton, Laszlo Papp, Rainer Leitgeb, Wolfgang Drexler, Angelika Unterhuber, and Marco Andreana "Identification of cardiac scar by extending multimodal optical imaging with multiparametric analysis and radiomics", Proc. SPIE PC12371, Multimodal Biomedical Imaging XVIII, PC1237102 (6 March 2023); https://doi.org/10.1117/12.2649151

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