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7 March 2022 Involvement of the cytoplasmic membrane viscosity of tumor cells in response to chemotherapy with platinum-based drugs
Liubov E. Shimolina, Marina Kuimova, Maria Lukina, Nadezhda Ignatova, Irina Druzhkova, Marina Shirmanova
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Proceedings Volume PC11965, Multiphoton Microscopy in the Biomedical Sciences XXII; PC119650J (2022) https://doi.org/10.1117/12.2606791
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
In this work, we investigate the changes of microviscosity in cancer cells exposed to chemotherapy with cisplatin and oxaliplatin. We analyzed the plasma membrane viscosity using fluorescent molecular rotor and fluorescence lifetime imaging. Our results in vitro show a significant increase in viscosity after treatment, which correlated with membrane lipid composition. The obtained data indicate the involvement of plasma membrane in the mechanisms of the platinum drug action.
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Liubov E. Shimolina, Marina Kuimova, Maria Lukina, Nadezhda Ignatova, Irina Druzhkova, and Marina Shirmanova "Involvement of the cytoplasmic membrane viscosity of tumor cells in response to chemotherapy with platinum-based drugs", Proc. SPIE PC11965, Multiphoton Microscopy in the Biomedical Sciences XXII, PC119650J (7 March 2022); https://doi.org/10.1117/12.2606791
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KEYWORDS
Tumors
Cancer
Fluorescence lifetime imaging
Colorectal cancer
In vitro testing
Laser scanners
Microscopes
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