Depth-recognizable time-domain fluorescence molecular tomography in reflectance geometry

Jiaju Cheng; Peng Zhang; Chuangjian Cai; Yang Gao; Jie Liu; Hui Hui; Jie Tian; Jianwen Luo

doi:10.1117/12.2602483

9 October 2021 Depth-recognizable time-domain fluorescence molecular tomography in reflectance geometry

Jiaju Cheng, Peng Zhang, Chuangjian Cai, Yang Gao, Jie Liu, Hui Hui, Jie Tian, Jianwen Luo

Proceedings Volume 11900, Optics in Health Care and Biomedical Optics XI; 1190007 (2021) https://doi.org/10.1117/12.2602483
Event: SPIE/COS Photonics Asia, 2021, Nantong, JS, China

Abstract

Utilizing reflective photons could circumvent the penetration limit of FMT, enabling reconstruction of fluorescence distribution near the surface regard less of the object size and extending its applications to surgical navigation and so on. Therefore, a time-domain reflective fluorescence molecular tomography (TD-rFMT) is proposed. The system excites and detects the emission light from the same angle within a field of view of 5 cm. Because the detected intensities of targets depend strongly on the depth, the reconstruction of targets in deep regions would be evidently affected. Therefore, a fluorescence yield reconstruction method with depth regularization and a weighted separation reconstruction strategy for lifetime are developed to enhance the performance for deep targets. Through simulations and phantom experiments, TD-rFMT is proved capable of reconstructing fluorescence distribution within a 2.5-cm depth with accurate reconstructed yield, lifetime, and target position(s).

Conference Presentation

Citation Download Citation

Jiaju Cheng, Peng Zhang, Chuangjian Cai, Yang Gao, Jie Liu, Hui Hui, Jie Tian, and Jianwen Luo "Depth-recognizable time-domain fluorescence molecular tomography in reflectance geometry", Proc. SPIE 11900, Optics in Health Care and Biomedical Optics XI, 1190007 (9 October 2021); https://doi.org/10.1117/12.2602483

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