Imaging and spectroscopy with scattered light from the tissue to chromatin scale

Mark Coughlan; Maria Glyavina; Xuejun Zhang; Umar Khan; Yuri N. Zakharov; Edward Vitkin; Lei Zhang; Irving Itzkan; Douglas K. Pleskow; Le Qiu; Lev T. Perelman

doi:10.1117/12.2590876

5 March 2021 Imaging and spectroscopy with scattered light from the tissue to chromatin scale

Mark Coughlan, Maria Glyavina, Xuejun Zhang, Umar Khan, Yuri N. Zakharov, Edward Vitkin, Lei Zhang, Irving Itzkan, Douglas K. Pleskow, Le Qiu, Lev T. Perelman

Author Affiliations +

Proceedings Volume 11622, Multiscale Imaging and Spectroscopy II; 116220D (2021) https://doi.org/10.1117/12.2590876
Event: SPIE BiOS, 2021, Online Only

Abstract

In this talk, we will discuss how scattered light can be used for noninvasive detection of invisible pre-cancer in organs such as the esophagus or pancreas which seem to have little in common. Nevertheless, since pre-cancer in many organs is characterized by certain common microscopic changes in the epithelial cells, such as the increase in nuclear size and nuclear density, we will show that light scattering signatures of those pre-cancers are quite similar, allowing for early cancer imaging and detection without the need for external markers. Light scattering signatures can also be used for sensing subnuclear and subcelluar structures, such as chromatin packing, organelle organization, and characterization of cell-derived exosomes. Nanoscale changes in the nuclear structure have been shown to play a critical role in genetic and transcriptional alterations and are a hallmark of neoplasia. We will discuss how the approach based on the combination of confocal microscopy and spectroscopy

Conference Presentation

Citation Download Citation

Mark Coughlan, Maria Glyavina, Xuejun Zhang, Umar Khan, Yuri N. Zakharov, Edward Vitkin, Lei Zhang, Irving Itzkan, Douglas K. Pleskow, Le Qiu, and Lev T. Perelman "Imaging and spectroscopy with scattered light from the tissue to chromatin scale", Proc. SPIE 11622, Multiscale Imaging and Spectroscopy II, 116220D (5 March 2021); https://doi.org/10.1117/12.2590876

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available