|
Multi-atlas segmentation methods will benefit from atlases covering the complete spectrum of population patterns, while the difficulties in generating such large enough datasets and the computation burden required in the segmentation procedure reduce its practicality in clinical application. In this work, we start from a viewpoint that different parts of the target object can be recognized by different atlases and propose a precision atlas selection strategy. By comparing regional similarity between target image and atlases, precision atlases are ranked and selected by the frequency of regional best match, which have no need to be globally similar to the target subject at either image-level or object-level, largely increasing the implicit patterns contained in the atlas set. In the proposed anatomy recognition method, atlas building is first achieved by all-totemplate registration, where the minimum spanning tree (MST) strategy is used to select a registration template from a subset of radiologically near-normal images. Then, a two-stage recognition process is conducted: in rough recognition, sub-image level similarity is calculated between the test image and each image of the whole atlas set, and only the atlas with the highest similarity contributes to the recognition map regionally; in refined recognition, the atlases with the highest frequencies of best match are selected as the precision atlases and are utilized to further increase the accuracy of boundary matching. The proposed method is demonstrated on 298 computed tomography (CT) images and 9 organs in the Head and Neck (HN) body region. Experimental results illustrate that our method is effective for organs with different segmentation challenge and samples with different image quality, where remarkable improvement in boundary interpretation is made by refined recognition and most objects achieve a localization error within 2 voxels.
|
