CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 11624 > Article
Presentation
5 March 2021 Quantitative hyperspectral microscopy for evaluating nanoparticle biodistribution in histological sections with single particle sensitivity
Elliott D. SoRelle, Orly Liba, Jos L. Campbell, Roopa Dalal, Cristina L Zavaleta, Adam de la Zerda
Author Affiliations +
Proceedings Volume 11624, Visualizing and Quantifying Drug Distribution in Tissue V; 116240A (2021) https://doi.org/10.1117/12.2579530
Event: SPIE BiOS, 2021, Online Only
Abstract
Nanoscale materials are routinely developed, characterized, and evaluated as diagnostic and therapeutic agents for disease treatment in humans. However, the size and composition of many such agents result in poor clearance profiles within biological tissues, thereby posing profound challenges to translational clinical applications. Herein, we present a hyperspectral imaging technique capable of quantifying plasmonic nanoparticle biodistribution with single particle limit of detection and microanatomical detail. Using this method, we find that, although intravenous administration of plasmonic nanoparticles remains largely infeasible from a biodistribution perspective, alternate routes relevant to treatment of oral and gastrointestinal diseases are within translational reach.
Conference Presentation
© (2021) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Elliott D. SoRelle, Orly Liba, Jos L. Campbell, Roopa Dalal, Cristina L Zavaleta, and Adam de la Zerda "Quantitative hyperspectral microscopy for evaluating nanoparticle biodistribution in histological sections with single particle sensitivity", Proc. SPIE 11624, Visualizing and Quantifying Drug Distribution in Tissue V, 116240A (5 March 2021); https://doi.org/10.1117/12.2579530
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Nanoparticles
Particles
Microscopy
Tissues
Plasmonics
Kidney
Liver
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top