Design and testing of fluorescence-guided endoscopic biopsy assessment at the bedside

Mark E. Fauver; Yang Jiang; Matthew D. Carson; Sean X. Gui; Eric J. Seibel

doi:10.1117/12.2579374

5 March 2021 Design and testing of fluorescence-guided endoscopic biopsy assessment at the bedside

Mark E. Fauver, Yang Jiang, Matthew D. Carson, Sean X. Gui, Eric J. Seibel

Proceedings Volume 11633, Design and Quality for Biomedical Technologies XIV; 116330H (2021) https://doi.org/10.1117/12.2579374
Event: SPIE BiOS, 2021, Online Only

Abstract

Clinical detection of premalignant lesions often requires labeling with molecular probes. In the gastrointestinal tract, most cancers originate in epithelial layers which are interrogated using topically-applied probes with conjugated fluorescence dyes. As part of clinical trials using fluorescence peptide probes, we have developed two different instruments that rapidly image the biopsy at the bedside before fixation. These multimodal images (visible light reflectance and near infrared fluorescence) provide verification that the targeted lesion was sampled, and provide feedback to the clinician at the bedside for any follow-up procedure. Performance of these two prototypes are compared for fluorescence sensitivity and multimodal image quality.

Conference Presentation

Citation Download Citation

Mark E. Fauver, Yang Jiang, Matthew D. Carson, Sean X. Gui, and Eric J. Seibel "Design and testing of fluorescence-guided endoscopic biopsy assessment at the bedside", Proc. SPIE 11633, Design and Quality for Biomedical Technologies XIV, 116330H (5 March 2021); https://doi.org/10.1117/12.2579374

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available