Brian White,1 Tiffany Kohttps://orcid.org/0000-0002-5113-0310,1 Ryan W. Morgan,1 Jharna Jahnavi,1 Emilie M. Benson,2 Anna L. Roberts,1 Kristen N. Andersen,1 Thomas Hallowell,1 Yuxi Lin,1 Jake Breimann,1 Jonah A. Padawer-Curry,1 Timothy Benson,1 Kathryn Graham,1 William P. Landis,1 Nile Delso,1 Giselle Matlis,1 Robert A. Berg,1 Arjun Yodh,2 Daniel J. Licht,1 Todd J. Kilbaugh1
1The Children's Hospital of Philadelphia (United States) 2Univ. of Pennsylvania (United States)
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Evaluation of the brain’s resting-state is an important window into neuronal function, connectivity, and health. Resting-state brain activity is reflected via neurovascular coupling in low frequency (0.01-0.1 Hz) hemodynamics, and low frequency power (LFP) can be a proxy for regional neuronal activity. In this exploratory study, we measured LFP in cerebral blood flow using diffuse correlation spectroscopy (LFP-DCS) during the course of an asphyxial cardiac arrest model in pediatric swine. The data demonstrate that LFP-DCS has distinct temporal information to blood flow index and may provide an additional biomarker to predict successful recovery after neurologic insults.
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Brian White, Tiffany Ko, Ryan W. Morgan, Jharna Jahnavi, Emilie M. Benson, Anna L. Roberts, Kristen N. Andersen, Thomas Hallowell, Yuxi Lin, Jake Breimann, Jonah A. Padawer-Curry, Timothy Benson, Kathryn Graham, William P. Landis, Nile Delso, Giselle Matlis, Robert A. Berg, Arjun Yodh, Daniel J. Licht, Todd J. Kilbaugh, "Low frequency power in cerebral blood flow through cardiac arrest and recovery in a swine model," Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 116290D (5 March 2021); https://doi.org/10.1117/12.2578832