NNeMo (Neonatal NeuroMonitor): a non-invasive brain monitor for continuous acquisition of cerebral blood flow and cytochrome c oxidase in the premature brain

Ajay Rajaram; Lawrence C. M. Yip; Marianne Suwalski; Daniel Milej; Lilian Kebaya; Matthew Kewin; Mamadou Diop; Sandrine de Ribaupierre; Soume Bhattacharya; Keith St. Lawrence

doi:10.1117/12.2578721

5 March 2021 NNeMo (Neonatal NeuroMonitor): a non-invasive brain monitor for continuous acquisition of cerebral blood flow and cytochrome c oxidase in the premature brain

Ajay Rajaram, Lawrence C. M. Yip, Marianne Suwalski, Daniel Milej, Lilian Kebaya, Matthew Kewin, Mamadou Diop, Sandrine de Ribaupierre, Soume Bhattacharya, Keith St. Lawrence

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Proceedings Volume 11639, Optical Tomography and Spectroscopy of Tissue XIV; 1163916 (2021) https://doi.org/10.1117/12.2578721
Event: SPIE BiOS, 2021, Online Only

Abstract

The premature brain embodies an underdeveloped vascular system, which can lead to poor cerebral blood flow (CBF), impaired metabolism, and subsequent brain injury. NNeMo (Neonatal NeuroMonitor) is an in-house built brain monitor that provides continuous and simultaneous measurements of CBF, tissue saturation (StO2), and metabolism. Nine premature infants were monitored for 6 h on day 1 and 3 of life. An oscillatory signal was observed in CBF and StO2 which diminished by day 3; metabolic response was not impacted by minor fluctuations in perfusion. Hemodynamic neuromonitoring could aid in predicting the onset of cerebral hemorrhaging or gauging brain injury severity.

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Ajay Rajaram, Lawrence C. M. Yip, Marianne Suwalski, Daniel Milej, Lilian Kebaya, Matthew Kewin, Mamadou Diop, Sandrine de Ribaupierre, Soume Bhattacharya, and Keith St. Lawrence "NNeMo (Neonatal NeuroMonitor): a non-invasive brain monitor for continuous acquisition of cerebral blood flow and cytochrome c oxidase in the premature brain", Proc. SPIE 11639, Optical Tomography and Spectroscopy of Tissue XIV, 1163916 (5 March 2021); https://doi.org/10.1117/12.2578721

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KEYWORDS

Brain

Cerebral blood flow

Mode conditioning cables

Near infrared spectroscopy

Traumatic brain injury

Control systems

Injuries

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