SOLUS: an innovative multimodal imaging system to improve breast cancer diagnosis through diffuse optics and ultrasounds

Antonio Pifferi; Alberto Dalla Mora; Laura Di Sieno; Edoardo Ferocino; Alberto Tosi; Enrico Conca; Vincenzo Sesta; Andrea Giudice; Alessandro Ruggeri; Simone Tisa; Alexander Flocke; Bogdan Rosinski; Jean-Marc Dinten; Mathieu Perriollat; Christophe Fraschini; Hélène Sportouche; Simon Arridge; Giuseppe Di Sciacca; Andrea Farina; Pietro Panizza; Elena Venturini; Peter Gordebeke; Pamela Zolda; Paola Taroni

doi:10.1117/12.2576778

5 March 2021 SOLUS: an innovative multimodal imaging system to improve breast cancer diagnosis through diffuse optics and ultrasounds

Antonio Pifferi, Alberto Dalla Mora, Laura Di Sieno, Edoardo Ferocino, Alberto Tosi, Enrico Conca, Vincenzo Sesta, Andrea Giudice, Alessandro Ruggeri, Simone Tisa, Alexander Flocke, Bogdan Rosinski, Jean-Marc Dinten, Mathieu Perriollat, Christophe Fraschini, Hélène Sportouche, Simon Arridge, Giuseppe Di Sciacca, Andrea Farina, Pietro Panizza, Elena Venturini, Peter Gordebeke, Pamela Zolda, Paola Taroni

Author Affiliations +

Proceedings Volume 11639, Optical Tomography and Spectroscopy of Tissue XIV; 116390C (2021) https://doi.org/10.1117/12.2576778
Event: SPIE BiOS, 2021, Online Only

Abstract

To improve non-invasively the specificity in the diagnosis of breast cancer after a positive screening mammography or doubt/suspicious ultrasound examination, the SOLUS project developed a multimodal imaging system that combines: Bmode ultrasound (US) scans (to assess morphology), Color Doppler (to visualize vascularization), shear-wave elastography (to measure stiffness), and time domain multi-wavelength diffuse optical tomography (to estimate tissue composition in terms of oxy- and deoxy-hemoglobin, lipid, water, and collagen concentrations). The multimodal probe arranges 8 innovative photonic modules (optodes) around the US transducer, providing capability for optical tomographic reconstruction. For more accurate estimate of lesion composition, US-assessed morphological priors can be used to guide the optical reconstructions. Each optode comprises: i) 8 picosecond pulsed laser diodes with different wavelengths, covering a wide spectral range (635-1064 nm) for good probing of the different tissue constituents; ii) a large-area (variable, up to 8.6 mm² ) fast-gated digital Silicon Photomultiplier; iii) the acquisition electronics to record the distribution of time-of-flight of the re-emitted photons. The optode is the basic element of the optical part of the system, but is also a stand-alone, ultra-compact (about 4 cm³ ) device for time domain multi-wavelength diffuse optics, with potential application in various fields.

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Antonio Pifferi, Alberto Dalla Mora, Laura Di Sieno, Edoardo Ferocino, Alberto Tosi, Enrico Conca, Vincenzo Sesta, Andrea Giudice, Alessandro Ruggeri, Simone Tisa, Alexander Flocke, Bogdan Rosinski, Jean-Marc Dinten, Mathieu Perriollat, Christophe Fraschini, Hélène Sportouche, Simon Arridge, Giuseppe Di Sciacca, Andrea Farina, Pietro Panizza, Elena Venturini, Peter Gordebeke, Pamela Zolda, and Paola Taroni "SOLUS: an innovative multimodal imaging system to improve breast cancer diagnosis through diffuse optics and ultrasounds", Proc. SPIE 11639, Optical Tomography and Spectroscopy of Tissue XIV, 116390C (5 March 2021); https://doi.org/10.1117/12.2576778

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