Using a diagnostic ultrasound system for photo-mediated ultrasound therapy

Yu Qin; Yunhao Zhu; Yixin Yu; Yannis Mantas Paulus; Xinmai Yang; Xueding Wang

doi:10.1117/12.2576602

5 March 2021 Using a diagnostic ultrasound system for photo-mediated ultrasound therapy

Yu Qin, Yunhao Zhu, Yixin Yu, Yannis Mantas Paulus, Xinmai Yang, Xueding Wang

Proceedings Volume 11642, Photons Plus Ultrasound: Imaging and Sensing 2021; 116422A (2021) https://doi.org/10.1117/12.2576602
Event: SPIE BiOS, 2021, Online Only

Abstract

Photo-mediated ultrasound therapy (PUT) is a novel, non-invasive, and agent-free therapeutic technique that uses a combination of relatively low-intensity ultrasound bursts and nanosecond laser pulses to selectively and precisely remove highly optically absorptive targets. In this work, we developed an integrated ultrasound photoacoustic theranostic system (UPTS) by combining a ultrasound system (V1, Verasonics) with a pulsed laser system. The results from the ex vivo experiments in rabbit tissues demonstrated that UPTS, by working with appropriate laser wavelengths, can selectively remove tissues such as knee tendon and liver via the cavitation synergistically created by the ultrasound bursts and the laser pulses. Such a theranostic system can deliver effective PUT treatment to biological samples along with real-time monitoring by the integrated ultrasound and photoacoustic imaging.

Conference Presentation

Citation Download Citation

Yu Qin, Yunhao Zhu, Yixin Yu, Yannis Mantas Paulus, Xinmai Yang, and Xueding Wang "Using a diagnostic ultrasound system for photo-mediated ultrasound therapy", Proc. SPIE 11642, Photons Plus Ultrasound: Imaging and Sensing 2021, 116422A (5 March 2021); https://doi.org/10.1117/12.2576602

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