Assembly of a PDT device with a near-infrared fluorescence monitoring of PpIX during treatment

Marlon R. Garcia; Sebastião Pratavieira; Lilian T. Moriyama; Cristina Kurachi; Daniel V. Magalhães

doi:10.1117/12.2507344

28 February 2019 Assembly of a PDT device with a near-infrared fluorescence monitoring of PpIX during treatment

Marlon R. Garcia, Sebastião Pratavieira, Lilian T. Moriyama, Cristina Kurachi, Daniel V. Magalhães

Proceedings Volume 10860, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII; 108600T (2019) https://doi.org/10.1117/12.2507344
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

This paper describes the assembly and characterization of a system to treat and monitor ALA-based photodynamic therapy, using near-infrared fluorescence images for photosensitizer monitoring. The system is portable, user friendly and low cost, using a diode laser emitting at 633 nm as treatment light, capable to delivery up to 150 mW/cm² at the lesion surface. The PpIX fluorescence is excited by the treatment light itself, and detected by camera in real-time. Since the excitation and emission wavelengths are in the red-NIR spectral regions, the penetration into the skin is improved and the volume measured by the fluorescence images is larger when compared to the widely used violet excitation.

Citation Download Citation

Marlon R. Garcia, Sebastião Pratavieira, Lilian T. Moriyama, Cristina Kurachi, and Daniel V. Magalhães "Assembly of a PDT device with a near-infrared fluorescence monitoring of PpIX during treatment", Proc. SPIE 10860, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII, 108600T (28 February 2019); https://doi.org/10.1117/12.2507344

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