Multimodal optical imaging as breast cancer margins assessment methods

Ekaterina V. Gubarkova; Vadim V. Elagin; Alexander A. Moiseev; Marina A. Sirotkina; Nadezhda P. Pavlova; Sergei S. Kuznetsov; Dmitry A. Vorontsov; Alexey Yu. Vorontsov; Grigory V. Gelikonov; Elena V. Zagaynova; Natalia D. Gladkova

doi:10.1117/12.2506865

22 February 2019 Multimodal optical imaging as breast cancer margins assessment methods

Ekaterina V. Gubarkova, Vadim V. Elagin, Alexander A. Moiseev, Marina A. Sirotkina, Nadezhda P. Pavlova, Sergei S. Kuznetsov, Dmitry A. Vorontsov, Alexey Yu. Vorontsov, Grigory V. Gelikonov, Elena V. Zagaynova, Natalia D. Gladkova

Author Affiliations +

Proceedings Volume 10867, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII; 108673F (2019) https://doi.org/10.1117/12.2506865
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

In this study we combined cross-polarization optical coherence tomography (CP OCT), multiphoton tomography (MPT), based on second harmonic generation, and two-photon-excited fluorescence to visualize collagen fibers and tumor cells in the various morphological subtypes of breast cancer. The ability of CP OCT to visualize tissue birefringence and cross-scattering adds new information about the microstructure of such breast cancers, while the MPT provides verification of this microstructure. Mammary glands, both normal and tumorous, were assessed by MPT and CP OCT to establish the relationships between spatial organization features of the cellular component and the intercellular matrix. It was shown, that such multimodal optical imaging has great potential for distinguishing various breast cancer morphological subtypes and could provide useful tools for identifying positive breast cancer margins for surgery.

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Ekaterina V. Gubarkova, Vadim V. Elagin, Alexander A. Moiseev, Marina A. Sirotkina, Nadezhda P. Pavlova, Sergei S. Kuznetsov, Dmitry A. Vorontsov, Alexey Yu. Vorontsov, Grigory V. Gelikonov, Elena V. Zagaynova, and Natalia D. Gladkova "Multimodal optical imaging as breast cancer margins assessment methods", Proc. SPIE 10867, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII, 108673F (22 February 2019); https://doi.org/10.1117/12.2506865

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