Analysis of albumin Raman scattering in visible and near-infrared ranges

Anastasia A. Lykina; Dmitry N. Artemyev

doi:10.1117/12.2317535

26 April 2018 Analysis of albumin Raman scattering in visible and near-infrared ranges

Proceedings Volume 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX; 107160E (2018) https://doi.org/10.1117/12.2317535
Event: Saratov Fall Meeting 2017, 2017, Saratov, Russian Federation

Abstract

In this work the analysis of the shape and intensity of albumin Raman signals in visible and near-IR ranges was carried out. The experimental setup using lasers from the visible region first of all excites the fluorescence of the albumin solution, the main contribution to which is produced by sodium chloride, which is a component of the tested sample. At the same time, lasers from the near-infrared range excited the Raman signal of albumin most effectively. It was found that the highest ratio of Raman scattering to autofluorescence intensities in the detected signal was obtained using a laser with a wavelength of 1064 nm. To determine the albumin solution concentration by type of spectrum, a regression approach with the projection to latent structures method was applied. The lowest predicted error of albumin concentration of 2-3 g/l was obtained by using the near-infrared range lasers.

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Anastasia A. Lykina and Dmitry N. Artemyev "Analysis of albumin Raman scattering in visible and near-infrared ranges", Proc. SPIE 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX, 107160E (26 April 2018); https://doi.org/10.1117/12.2317535

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KEYWORDS

Raman spectroscopy

Signal detection

Remote sensing

Near infrared

Sodium

Visible radiation

Raman scattering

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