血液疾患に併発した深在性真菌症に対するミコナゾール点滴静注液剤 (MJR-1761) の有効性・安全性の臨床的検討

川田 浩志; 米倉 修司; 増本 暁; 小川 吉明; 福田 竜基; 笹尾 保; 渡辺 茂樹; 有森 香; 藤原 光; 堀木 照美; 佐藤 浩司; 梅田 祥克; 大林 由明; 市川 幸延; 長尾 忠美

doi:10.11150/kansenshogakuzasshi1970.68.775

Clinical Studies of a Newly Developed Miconazole Preparation for Intravenous Drip Infusion (MJR-1761) in Hematologic Disease Patients with Deep-Seated Fungal Infection

Hiroshi KAWADA, Shuji YONEKURA, Akira MASUMOTO, Yoshiaki OGAWA, Ryuki FUKUDA, Tamotsu SASAO, Shigeki WATANABE, Kaori ARIMORI, Hikaru FUJIWARA, Terumi HORIKI, Hiroshi SATO, Yoshikatsu UMEDA, Yoshiaki OHBAYASHI, Yukinobu ICHIKAWA, Tadami NAGAO

Author information

Hiroshi KAWADA
The Fourth Department of Internal Medicine, Tokai University School of Medicine
Shuji YONEKURA
The Fourth Department of Internal Medicine, Tokai University School of Medicine
Akira MASUMOTO
The Fourth Department of Internal Medicine, Tokai University School of Medicine
Yoshiaki OGAWA
The Fourth Department of Internal Medicine, Tokai University School of Medicine
Ryuki FUKUDA
The Fourth Department of Internal Medicine, Tokai University School of Medicine
Tamotsu SASAO
The Fourth Department of Internal Medicine, Tokai University School of Medicine
Shigeki WATANABE
The Fourth Department of Internal Medicine, Tokai University School of Medicine
Kaori ARIMORI
The Fourth Department of Internal Medicine, Tokai University School of Medicine
Hikaru FUJIWARA
The Fourth Department of Internal Medicine, Tokai University School of Medicine
Terumi HORIKI
The Fourth Department of Internal Medicine, Tokai University School of Medicine
Hiroshi SATO
The Fourth Department of Internal Medicine, Tokai University School of Medicine
Yoshikatsu UMEDA
The Fourth Department of Internal Medicine, Tokai University School of Medicine
Yoshiaki OHBAYASHI
The Fourth Department of Internal Medicine, Tokai University School of Medicine
Yukinobu ICHIKAWA
The Fourth Department of Internal Medicine, Tokai University School of Medicine
Tadami NAGAO
The Fourth Department of Internal Medicine, Tokai University School of Medicine

Keywords: MJR-1761, miconazole, hematological disease, fungal infection

JOURNAL FREE ACCESS

1994 Volume 68 Issue 6 Pages 775-783

DOI https://doi.org/10.11150/kansenshogakuzasshi1970.68.775

[Correction] kansenshogakuzasshi Vol.68 No.11 (1994) pp.1440a-1440a

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Abstract

The efficacy and safety of a newly developed miconazole preparation (MJR-1761) for intravenous drip infusion were evaluated in 22 patients with hematological diseases complicated by documented or suspected deep-seated fungal infections. They consisted of 15 patients with fungemia, 2 patients with pulmonary mycosis, and 5 patients with mycosis of the digestive tract. Of the 5 patients, 3 had a complication of fungemia and 1 a complication of urinary tract mycosis. Of the 22 patients, 21 were clinically evaluable. All the patients were included in safety evaluation. The effective rate was 86%(18/21) when moderately improved or better evaluations were included, and the usefulness rate was 81%(17/21) when moderately or more useful evaluations were taken into consideration. Side effects occurred in 4 patients, and abnormal laboratory values were obtained in 4 patients. All these changes, which were previously reported, improved after the discontinuation of the treatment. The results presented indicate that the miconazole intravenous drip infusion solution used in this study is as effective as conventional similar preparations. Since the infusion solution need not be diluted immediately before use, it is simple to use, and its safety may be highly rated. The purpose can be met with less volume of solution per use than before because the preparation contains as much as 200 mg of miconazole in 75 ml of solution. This preparation seems to lend itself better to clinical application than conventional similar infusion solutions.

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